Factors Associated with Lymph Node Count in Mucosal Squamous Cell Carcinoma Neck Dissection

Objective/Hypothesis Decreased lymph node count (LNC) from neck dissection (ND) for mucosal head and neck squamous cell carcinoma (HNSCC) patients is correlated with decreased survival. Advanced age and low BMI due to undernutrition from dysphagia from advanced T‐stage tumors are common in patients...

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Bibliographic Details
Published in:The Laryngoscope 2021-07, Vol.131 (7), p.1516-1521
Main Authors: Bhalli, Hamza, Chen, Shuqing, Day, Andrew, Tillman, Brittny, Gordin, Eli, Truelson, John, Sher, David, Myers, Larry, Gao, Jinming, Sumer, Baran D.
Format: Article
Language:English
Subjects:
body mass index
Dissection
extracapsular extension
Head & neck cancer
Head and neck squamous cell carcinoma
immunocompromised
Laryngoscopy
lymph node count
Lymphatic system
Medical prognosis
neck dissection
nodal yield
p16
Squamous cell carcinoma
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Summary:Objective/Hypothesis Decreased lymph node count (LNC) from neck dissection (ND) for mucosal head and neck squamous cell carcinoma (HNSCC) patients is correlated with decreased survival. Advanced age and low BMI due to undernutrition from dysphagia from advanced T‐stage tumors are common in patients with HNSCC. We studied the relationship between these two well‐described causes for immune dysfunction and LNC in patients undergoing neck dissection. Study Design We conducted a retrospective review at a single tertiary care institution of patients with HNSCC that underwent neck dissection from 2006 to 2017. Methods Stepwise linear and logistic regression analyses were performed on 247 subjects to identify independent significant factors associated with 1) the LNC per neck level dissected; 2) advanced T‐stage. One‐way ANOVA was utilized to demonstrate differences between the p16 positive and negative subgroups. Results Low BMI (
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.29353