Cardiac Adipose Tissue Contributes to Cardiac Repair: a Review

Cardiac adipose tissue is a metabolically active adipose tissue in close proximity to heart. Recent studies emphasized the benefits of cardiac adipose tissue in heart remodeling, such as reducing infarction size, enhancing neovascularization and regulating immune response, through a series of cellul...

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Bibliographic Details
Published in:Stem cell reviews and reports 2021-08, Vol.17 (4), p.1137-1153
Main Authors: Lin, Yan, Ding, Siyin, Chen, Yuwen, Xiang, Meixiang, Xie, Yao
Format: Article
Language:English
Subjects:
Adipocytes
Adipose tissue
Adipose Tissue - cytology
Apoptosis
Atrial Remodeling
Biomedical and Life Sciences
Biomedical Engineering and Bioengineering
Body fat
Cardiomyocytes
Cardiovascular disease
Cell Biology
Cell Differentiation
Coronary vessels
Cytokines
Gene expression
Heart
Heart attacks
Heart failure
Humans
Immune response
Infarction
Ischemia
Life Sciences
Lipids
Mortality
Multipotent Stem Cells
Physiology
Regenerative Medicine/Tissue Engineering
Reviews
Smooth muscle
Stem Cell Transplantation
Stem Cells
Vascularization
Vein & artery diseases
Ventricular Remodeling
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Summary:Cardiac adipose tissue is a metabolically active adipose tissue in close proximity to heart. Recent studies emphasized the benefits of cardiac adipose tissue in heart remodeling, such as reducing infarction size, enhancing neovascularization and regulating immune response, through a series of cellular mechanisms. In the present manuscript, we provide a comprehensive review regarding the role of cardiac adipose tissue in cardiac repair. We focus on different cardiac adipose tissues according to their distinguished anatomical structures. This review summarizes the latest evidence on the relationship between cardiac adipose tissue and cardiac repair. Graphical Abstract Cardiac adipose tissues (CAT) were systematically reviewed in the current manuscript which focused on the components of CAT, debates about cardiac adipose stem cells and their effect on heart
ISSN:2629-3269
2629-3277
DOI:10.1007/s12015-020-10097-4