Effect of preoperative exercise on vascular caliber and maturation of arteriovenous fistula: the physicalfav trial, a randomized controlled study

Background and objectives Autologous arteriovenous fistula (AVF) is the best vascular access for hemodialysis. Distal forearm radiocephalic fistula is the best option, although the primary failure rate ranges from 20% to 50%. The main objective of the PHYSICALFAV trial was to evaluate the effect of...

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Bibliographic Details
Published in:Journal of nephrology 2021-06, Vol.34 (3), p.763-771
Main Authors: Aragoncillo Sauco, Ines, Hevia, Covadonga, Manzano Grossi, Soledad, Amezquita, Yesika, Macias, Nicolas, Caldes, Silvia, Ramirez Senent, Belen, Hernandez Hernandez, Yolanda, Goicoechea, Marian
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Nephrology
Original Article
Urology
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Summary:Background and objectives Autologous arteriovenous fistula (AVF) is the best vascular access for hemodialysis. Distal forearm radiocephalic fistula is the best option, although the primary failure rate ranges from 20% to 50%. The main objective of the PHYSICALFAV trial was to evaluate the effect of preoperative isometric exercise on vascular caliber, percentage of distal arteriovenous fistula, and primary failure rate. Design, setting, participants, and measurements The PHYSICALFAV trial (NCT03213756) is an open-label, multicenter, prospective, randomized, controlled trial (RCT). A total of 138 patients were randomized 1:1 to the exercise group (exercises combining a handgrip device and an elastic band for 8 weeks) or the control group (no exercise) and followed up with periodic Doppler ultrasound (DU) examinations. Results After 8 weeks of preoperative isometric exercise, in the exercise group, significant increases were detected in venous caliber (2.80 ± 0.95 mm vs 3.52 ± 0.93 mm [p 
ISSN:1121-8428
1724-6059
DOI:10.1007/s40620-020-00907-w