MirSNPs in clopidogrel metabolism genes predict cardiovascular disease risk: a case–control study and meta-analysis

The present study was conducted to decipher the inter-relationship of SNPs and miRNAs involved in pharmacogenomics of clopidogrel on predisposition to cardiovascular diseases (CVDs). A case–control study was conducted on 410 cases and 386 controls to analyze the association of 13 mirSNPs on CVDs ris...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacogenomics 2021-01, Vol.22 (2), p.99-113
Main Authors: Sharma, Anu Radha, Patagi, Sourav, Uk, Abdul Razak, Shetty, Ranjan, Umakanth, Shashikiran, Satyamoorthy, Kapaettu, Rai, Padmalatha S
Format: Article
Language:English
Subjects:
cardiovascular diseases
meta-analysis
miRNAs
mirSNPs
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present study was conducted to decipher the inter-relationship of SNPs and miRNAs involved in pharmacogenomics of clopidogrel on predisposition to cardiovascular diseases (CVDs). A case–control study was conducted on 410 cases and 386 controls to analyze the association of 13 mirSNPs on CVDs risk. Genotyping was performed by tetra-primer amplification refractory mutation system PCR and validated using Sanger DNA sequencing. miRNA expression analysis was performed using TaqMan assays. A meta-analysis was performed for rs662 with coronary artery disease. rs662, rs3917577, rs15524, rs874204 and rs1126510 polymorphisms showed association with CVDs. The miRNA hsa-miR-224-5p showed differential expression in the rs3917577 GG genotype. The meta-analysis showed the population-specific impact of rs662 on South Asian and Middle East populations.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs-2020-0110