Preliminary study on the relationship between pepsin and vocal fold polyp

With regard to the second point raised by Dr. Lechien, we also agree with the theory that LPR may lead to the alteration of the biomechanical properties in the mucous membrane of vocal cords, making it more susceptible to mechanical effects and biological pressures in vocalization, resulting in hoar...

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Bibliographic Details
Published in:American journal of otolaryngology 2021-03, Vol.42 (2), p.102835-102835, Article 102835
Main Authors: Li, Xiang-Ping, Dai, Yuan-Feng, Tan, Jia-Jie, Deng, Chao-Qun, Liu, Xiong, Lv, Ze-Hong
Format: Article
Language:English
Subjects:
Biological effects
Biomechanics
DNA damage
Humans
Laryngeal Diseases - complications
Laryngeal Diseases - diagnosis
Laryngeal Diseases - pathology
Laryngopharyngeal Reflux - complications
Laryngopharyngeal Reflux - diagnosis
Larynx
Mechanical properties
Mucosa
Pepsin
Pepsin A
Polyps
Polyps - diagnosis
Polyps - pathology
Vocal Cords
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Summary:With regard to the second point raised by Dr. Lechien, we also agree with the theory that LPR may lead to the alteration of the biomechanical properties in the mucous membrane of vocal cords, making it more susceptible to mechanical effects and biological pressures in vocalization, resulting in hoarseness and VFBL. [...]relevant literatures [6,7] were cited in the introduction and discussion section of our paper. [...]the study was also inspired by the views mentioned above, which suggested that laryngeal mucosal injury induced by pepsin, the main damage factor of LPR, might play an important role in the development and development of VFPs. [...]Hu [10] found that the LPR can widened the cell intercellular space (IS) of mucosa and destroyed the epithelial barrier by observed histological and electron microscopic results in the rabbit model.
ISSN:0196-0709
1532-818X
DOI:10.1016/j.amjoto.2020.102835