The role of Krüppel-like factor 8 in cancer biology: Current research and its clinical relevance

[Display omitted] Cancer is one of the leading causes of mortality worldwide, ranked second after heart disease. Despite recent advancements in diagnosis and treatment, there are still numerous problems associated with cancer progression, disease recurrence, and therapeutic resistance that are parti...

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Published in:Biochemical pharmacology 2021-01, Vol.183, p.114351-114351, Article 114351
Main Authors: Kumar, Sanjay, Behera, Abhijeet, Saha, Priyanka, Kumar Srivastava, Amit
Format: Article
Language:English
Subjects:
Animals
Biomedical Research - trends
Cancer stem cells
Chemoresistance
DNA Repair - physiology
EMT
Epithelial-Mesenchymal Transition - physiology
Function
Humans
KLF8
Kruppel-Like Transcription Factors - biosynthesis
Kruppel-Like Transcription Factors - chemistry
Kruppel-Like Transcription Factors - genetics
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Prognosis
Protein Structure, Secondary
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Summary:[Display omitted] Cancer is one of the leading causes of mortality worldwide, ranked second after heart disease. Despite recent advancements in diagnosis and treatment, there are still numerous problems associated with cancer progression, disease recurrence, and therapeutic resistance that are partially explored. Several studies have recently revealed that Krüppel-like factor 8 (KLF8) regulates transcription of genes linked with diverse biological processes, including proliferation, epithelial to mesenchymal transition (EMT), migration, invasion, and inflammation. KLF8 is expressed ubiquitously in mammalian cells, and its aberrant expression has been manifested with several cancer types. Earlier studies demonstrated the crucial role of KLF8 in DNA repair and resistance to apoptosis in numerous cancer types. Hence, studying the function of KLF8 from the perspective of cancer progression and therapy resistance would help develop a new therapeutic avenue. In this review, we summarize the clinical relevance of KLF8 expression in various malignancies, focusing on recent updates in EMT, cellular signaling, and cancer stem cells. We also address the contribution of KLF8 in development, DNA repair, chemoresistance, and its clinical utility as a predictive biomarker.
ISSN:0006-2952
1873-2968
DOI:10.1016/j.bcp.2020.114351