Perinatal and obstetric outcomes in singleton pregnancies following fresh versus cryopreserved blastocyst transfer: a meta-analysis

The transfer of cryopreserved blastocysts is increasing in IVF centres. However, little is known about the perinatal and obstetric outcomes of this procedure. In an attempt to further elucidate these issues, a systematic review and meta-analysis was conducted to compare cryopreserved transfer with f...

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Bibliographic Details
Published in:Reproductive biomedicine online 2021-02, Vol.42 (2), p.401-412
Main Authors: Conforti, Alessandro, Picarelli, Silvia, Carbone, Luigi, La Marca, Antonio, Venturella, Roberta, Vaiarelli, Alberto, Cimadomo, Danilo, Zullo, Fulvio, Rienzi, Laura, Ubaldi, Filippo Maria, Alviggi, Carlo
Format: Article
Language:English
Subjects:
Blastocyst
Cryopreserved cycles
Fresh cycles
Perinatal outcome
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Summary:The transfer of cryopreserved blastocysts is increasing in IVF centres. However, little is known about the perinatal and obstetric outcomes of this procedure. In an attempt to further elucidate these issues, a systematic review and meta-analysis was conducted to compare cryopreserved transfer with fresh blastocyst embryo transfer. The results show that the risk of both preterm (odds ratio [OR] 0.89, 95% confidence interval [CI] 0.80–0.99, P = 0.04) and low birthweight births (OR 0.82, 95% CI 0.68–0.99, P = 0.04) was significantly lower after cryopreserved blastocyst transfer than after fresh blastocyst transfer. The rate of large for gestational age births was significantly higher (OR 1.68, 95% CI 1.55–1.82, P 
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2020.09.029