AKT/mTOR Signal Cascade and Expression of PD-1, PD-L1, and PD-L2 in Gastric Cancer

The peculiarities of gastric cancer development associated with the expression levels of components of the AKT/mTOR signaling cascade and PD, PD-L1, PD-L2 have not yet been identified. We revealed the fundamental changes in the expression AKT/mTOR and PD receptors and their ligands associated with d...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2020-11, Vol.170 (1), p.75-78
Main Authors: Spirina, L. V., Avgustinovich, A. V., Afanas’ev, S. G., Kondakova, I. V., Volkov, M. Yu, Dobrodeev, A. Yu, Boronkina, A. I.
Format: Article
Language:English
Subjects:
AKT protein
Biomedical and Life Sciences
Biomedicine
Cell Biology
Gastric cancer
Internal Medicine
Laboratory Medicine
Ligands
Metastases
mRNA
Pathology
PD-1 protein
PD-L1 protein
PTEN protein
TOR protein
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Summary:The peculiarities of gastric cancer development associated with the expression levels of components of the AKT/mTOR signaling cascade and PD, PD-L1, PD-L2 have not yet been identified. We revealed the fundamental changes in the expression AKT/mTOR and PD receptors and their ligands associated with dissemination of gastric cancer. An increase in the mRNA level of all components of this cascade was demonstrated. The expression of mTOR and AKT decreased against the background of enhanced expression of PTEN phosphatase. The increase in the expression of PD-1 receptors and PD-L1 and PD-L2 ligands was most pronounced in patients with distant metastases.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-020-05007-0