Breast radiologic complete response is associated with favorable survival outcomes after neoadjuvant chemotherapy in breast cancer

The aim of this study was to examine the accuracy of radiologic complete response (rCR) in predicting pathologic complete response (pCR), and determine whether rCR is a predictor of favorable survival outcomes. We retrospectively reviewed breast cancer patients treated with neoadjuvant chemotherapy...

Full description

Saved in:
Bibliographic Details
Published in:European journal of surgical oncology 2021-02, Vol.47 (2), p.232-239
Main Authors: Woo, Jinsun, Ryu, Jai Min, Jung, Sung Mi, Choi, Hee Jun, Lee, Se Kyung, Yu, Jonghan, Lee, Jeong Eon, Kim, Seok Won, Nam, Seok Jin, Chae, Byung Joo
Format: Article
Language:English
Subjects:
Adult
Aged
Antineoplastic Agents - therapeutic use
Breast - pathology
Breast cancer
Breast Neoplasms - diagnosis
Breast Neoplasms - mortality
Breast Neoplasms - therapy
Chemotherapy, Adjuvant
Female
Humans
Magnetic Resonance Imaging - methods
Middle Aged
Neoadjuvant chemotherapy
Neoadjuvant Therapy
Neoplasm Staging - methods
Prognosis
Radiologic complete response
Republic of Korea - epidemiology
Retrospective Studies
Survival outcome
Survival Rate - trends
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of this study was to examine the accuracy of radiologic complete response (rCR) in predicting pathologic complete response (pCR), and determine whether rCR is a predictor of favorable survival outcomes. We retrospectively reviewed breast cancer patients treated with neoadjuvant chemotherapy (NAC) followed by surgery from September 2007 to June 2016. Breast lesions and axillary nodes were measured by MRI and categorized into either disappeared (breast rCR) or residual disease (breast non-rCR) and either normalized (axillary rCR) or abnormal findings (axillary non-rCR) in the axillary nodes. Correlation between rCR and pCR were compared using Cohen’s Kappa statistics, and the recurrence-free survival (RFS) and overall survival (OS) rates were calculated by the Kaplan-Meier method. Out of the 1017 eligible patients, 287 (28.2%) achieved breast pCR, 165 (16.2%) achieved breast rCR, 529 (52.0%) had axillary pCR, and 274 (26.9%) achieved axillary rCR. The correlation between a breast rCR and pCR showed a Cohen’s Kappa value of 0.459, and between axillary rCR and pCR, the value was 0.384. During a median follow-up time of 48.0 months, the 5-year RFS rates were 90.6% for breast rCR, and 69.2% for breast non-rCR. The 5-year RFS rates were 82.3% for axillary rCR, and 68.8% for axillary non-rCR. Patients without breast rCR had a 2.4-fold significant increase in the risk of recurrence (p = 0.004) compared to patients with breast rCR. Although rCR correlated with pCR by only moderate to fair degrees, breast rCR was a strong predictor for a favorable RFS outcome.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2020.08.023