A double‐blind randomized trial on subendometrial injection of vasopressin to control bleeding in postpartum hysterectomy due to abnormally invasive placenta

Objective To investigate the effect of subendometrial vasopressin injection in patients with abnormally invasive placenta (AIP), who underwent cesarean section and hysterectomy. Methods This randomized double‐blinded clinical trial was conducted on pregnant women diagnosed with AIP grade 4 and 5 by...

Full description

Saved in:
Bibliographic Details
Published in:International journal of gynecology and obstetrics 2021-05, Vol.153 (2), p.228-233
Main Authors: Ghotbizadeh Vhdani, Fahimeh, Nasiri Khormoji, Najmeh, Eftekhar, Negar, Deldar Pasikhani, Maryam, Hantoushzadeh, Sedigheh, Ghamari, Azin, Panahi, Zahra
Format: Article
Language:English
Subjects:
abnormally invasive placenta
cesarean section
hysterectomy
vasopressin
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To investigate the effect of subendometrial vasopressin injection in patients with abnormally invasive placenta (AIP), who underwent cesarean section and hysterectomy. Methods This randomized double‐blinded clinical trial was conducted on pregnant women diagnosed with AIP grade 4 and 5 by ultrasonography during cesarean section. Women were randomly divided into two equal groups including group 1 (vasopressin) and group 2 (control) who underwent 20 units of vasopressin and 20 cc normal saline injection, respectively. Vasopressin and placebo were injected subendometrially 1 cm medial to the uterine vessels into the lower uterine segment. The exclusion criteria include presence of myocardial infarction, cardiomyopathy, congestive heart failure, uncontrolled hypertension, chronic obstructive pulmonary disease, pelvic malignancy. The outcome of the study was total quantitative blood loss during the cesarean section. We estimated blood loss by measuring the blood volume in one of the suction bottles with addition for weight changes of mops, pads, and soaked linen savers. Results Sixty patients were recruited into the study, 30 as the vasopressin group and 30 as the controls; with no excluded case. The amount of bleeding in the vasopressin group was significantly lower compared with that in the control group (P 
ISSN:0020-7292
1879-3479
DOI:10.1002/ijgo.13440