Research on Cognitive Function in Anxious Depression Patients in China

•Anxious depression patients have more severe depressive symptoms but better cognitive functions, especially for verbal learning, compared with nonanxious depression patients.•After the acute treatment phase, executive function and attention/vigilance in anxious depression patients may be remitted....

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Bibliographic Details
Published in:Journal of affective disorders 2021-02, Vol.280 (Pt A), p.121-126
Main Authors: Duan, Yanping, Wei, Jing, Geng, Wenqi, Jiang, Jing, Zhao, Xiaohui, Li, Tao, Jiang, Yinan, Shi, Lili, Cao, Jinya, Zhu, Gang, Zhang, Kerang, Yu, Xin
Format: Article
Language:English
Subjects:
acute treatment phase
anxious depression
China
Cognition
cognitive function
Depression
Depressive Disorder, Major
Humans
major depressiv disorder
recovery
Treatment Outcome
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Summary:•Anxious depression patients have more severe depressive symptoms but better cognitive functions, especially for verbal learning, compared with nonanxious depression patients.•After the acute treatment phase, executive function and attention/vigilance in anxious depression patients may be remitted. Background: This study aimed to evaluate cognitive function in patients with anxious depression. Methods: This was a part of the “Objective Diagnostic Indicators and Individualized Drug Intervention of Major Depressive Disorder (MDD)” study. All participants, including patients with MDD and healthy controls (HCs), completed the 17-item Hamilton Depression Scale (HAMD17) and the Hamilton Anxiety Scale (HAMA). Anxious depression was defined as a HAMD17 anxiety/somatization factor score ≥7. Cognitive function was assessed at baseline and at the end of week 8. HC cognitive function was assessed at baseline. Results: A total of 1048 people were included in the analysis, including 328 patients in the anxious depression group (G1=328), 221 patients in the MDD without anxious depression group (G2=221), and 499 in the HC group (G3=499). There were significant differences in the HAMA at baseline (t=13.050, p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2020.11.078