The relationship between proteinuria and allograft survival in patients with transplant glomerulopathy: a retrospective single‐center cohort study

Summary Proteinuria and transplant glomerulopathy (TG) are common in kidney transplantation. To date, there is limited knowledge regarding proteinuria in different types of TG and its relationship to allograft survival. A retrospective cohort analysis of TG patients from indication biopsies was perf...

Full description

Saved in:
Bibliographic Details
Published in:Transplant international 2021-02, Vol.34 (2), p.259-271
Main Authors: Zhang, Qiang, Rudolph, Birgit, Choi, Mira, Bachmann, Friederike, Schmidt, Danilo, Duerr, Michael, Naik, Marcel G., Duettmann, Wiebke, Schrezenmeier, Eva, Mayrdorfer, Manuel, Halleck, Fabian, Wu, Kaiyin, Budde, Klemens
Format: Article
Language:English
Subjects:
Biopsy
Cohort analysis
Confidence intervals
Creatinine
Graft rejection
Graft-versus-host reaction
Grafting
Histology
Indication
Kidney transplantation
Kidney transplants
Proteinuria
Regression analysis
Risk analysis
Risk factors
Statistical analysis
Survival
survival analysis
transplant glomerulopathy
Transplants & implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Proteinuria and transplant glomerulopathy (TG) are common in kidney transplantation. To date, there is limited knowledge regarding proteinuria in different types of TG and its relationship to allograft survival. A retrospective cohort analysis of TG patients from indication biopsies was performed to investigate the relationship of proteinuria, histology, and graft survival. One hundred and seven (57.5%) out of 186 TG patients lost their grafts with a median survival of 14 [95% confidence interval (CI) 10–22] months after diagnosis. Proteinuria ≥1 g/24 h at the time of biopsy was detected in 87 patients (46.8%) and the median of proteinuria was 0.89 (range 0.05–6.90) g/24 h. TG patients with proteinuria ≥1 g/24 h had worse 5‐year graft survival (29.9% vs. 53.5%, P = 0.001) compared with proteinuria
ISSN:0934-0874
1432-2277
DOI:10.1111/tri.13787