Macrophage-Based Approaches for Cancer Immunotherapy

Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in hematologic malignancies, but its application to solid tumors has proven challenging. This gap has spurred the investigation of alternative immune cells as therapeutics. Macrophages are potent immune effector...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2021-03, Vol.81 (5), p.1201-1208
Main Authors: Anderson, Nicholas R, Minutolo, Nicholas G, Gill, Saar, Klichinsky, Michael
Format: Article
Language:English
Subjects:
Animals
Cell- and Tissue-Based Therapy - methods
Humans
Immunotherapy - methods
Immunotherapy, Adoptive - methods
Macrophages - pathology
Macrophages - transplantation
Neoplasms - pathology
Neoplasms - therapy
Tumor-Associated Macrophages - drug effects
Tumor-Associated Macrophages - pathology
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Summary:Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in hematologic malignancies, but its application to solid tumors has proven challenging. This gap has spurred the investigation of alternative immune cells as therapeutics. Macrophages are potent immune effector cells whose functional plasticity leads to antitumor as well as protumor function in different settings, and this plasticity has led to notable efforts to deplete or repolarize tumor-associated macrophages. Alternatively, macrophages could be adoptively transferred after genetic modification. In this review, we highlight the role of macrophages in solid tumors, the progress made with macrophage-focused immunotherapeutic modalities, and the emergence of chimeric antigen receptor macrophage cell therapy.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-20-2990