SLC30A8 gene polymorphism rs13266634 associated with increased risk for developing type 2 diabetes mellitus in Jordanian population

•The rs13266634 SNP is significantly associated with T2DM susceptibility.•The presence of the C risk allele increases T2DM susceptibility by 1.5 folds.•rs13266634 is a strong genetic candidate for individualizing those at risk of developing T2DM. Several genome-wide association studies (GWAS) have i...

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Bibliographic Details
Published in:Gene 2021-02, Vol.768, p.145279-145279, Article 145279
Main Authors: Mashal, Safaa, Khanfar, Mariam, Al-Khalayfa, Sawsan, Srour, Luma, Mustafa, Lina, Hakooz, Nancy M., Zayed, Ayman A., Khader, Yousef S., Azab, Bilal
Format: Article
Language:English
Subjects:
Case-Control Studies
Diabetes Mellitus, Type 2 - genetics
Female
Gene Frequency - genetics
Genetic Predisposition to Disease - genetics
Genome-Wide Association Study
Genotype
Humans
Jordan
Male
Middle Aged
Polymerase Chain Reaction
Polymerase chain reaction-restriction fragment length polymorphism
Polymorphism, Restriction Fragment Length - genetics
Polymorphism, Single Nucleotide - genetics
rs13266634
SLC30A8
Solute carrier family 30 member 8
Type 2 diabetes mellitus
Zinc Transporter 8 - genetics
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Summary:•The rs13266634 SNP is significantly associated with T2DM susceptibility.•The presence of the C risk allele increases T2DM susceptibility by 1.5 folds.•rs13266634 is a strong genetic candidate for individualizing those at risk of developing T2DM. Several genome-wide association studies (GWAS) have identified the single nucleotide polymorphism (SNP) rs13266634 in the Solute carrier family 30 member 8 (SLC30A8) gene as a risk factor to type 2 diabetes mellitus (T2DM). Nevertheless, other studies reported controversial findings of no significant association between the rs13266634 with T2DM. In this study, we aimed to investigate the association of this SNP with T2DM among Jordanian population in addition to define its corresponding allelic and genotypic frequencies. This case-control study enrolled 358 T2DM patients and 326 healthy controls who fulfilled the inclusion criteria. Blood samples were collected from all participants and were used for the rs13266634 SNP genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. We demonstrated a significant association between the C/T rs13266634 SNP and T2DM among Jordanian population. A significant difference was found between the cases and controls regarding the allelic (P = 0.003) distribution. Compared to people having T allele, those with C allele had higher risk of T2DM (OR = 1.47 ; 95% CI: 1.14 – 1.89; P = 0.003). Having a CC genotype versus TT genotype was significantly associated with increased risk to T2DM (OR = 2.44; 95% CI: 1.16 – 5.12; P = 0.019) after adjusting for age, gender, and BMI. Under the recessive model, subjects with CC genotype were more likely to have T2DM compared to those with CT or TT genotypes, (OR = 1.64; 95% CI: 1.18 – 2.26; P = 0.003) after adjusting for age, gender and BMI. The rs13266634 SNP is significantly associated with T2DM susceptibility among Jordanian Population.
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2020.145279