Role of vitamin D in pathogenesis and severity of COVID-19 infection

Coronavirus disease (COVID-19) is an infectious disease caused by a new virus that causes respiratory illness. Older adults and individuals who have pre-existing chronic medical conditions are at higher risk for more serious complications from COVID-19. Hypovitaminosis D is attributed to the increas...

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Bibliographic Details
Published in:Archives of physiology and biochemistry 2023-01, Vol.129 (1), p.26-32
Main Authors: Honardoost, Maryam, Ghavideldarestani, Maryam, Khamseh, Mohammad E.
Format: Article
Language:English
Subjects:
ACE2
Aged
cardiovascular disease
COVID-19
COVID-19 - complications
diabetes
Humans
Peptidyl-Dipeptidase A
Renin-Angiotensin System
SARS-CoV-2 - metabolism
Vitamin D
Vitamins - therapeutic use
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Summary:Coronavirus disease (COVID-19) is an infectious disease caused by a new virus that causes respiratory illness. Older adults and individuals who have pre-existing chronic medical conditions are at higher risk for more serious complications from COVID-19. Hypovitaminosis D is attributed to the increased risk of lung injury and acute respiratory distress syndrome (ARDS) as well as diabetes, cardiovascular events and associated comorbidities, which are the main causes of severe clinical complications in COVID-19 patients. Considering the defensive role of vitamin D, mediated through modulation of the innate and adaptive immune system as well as inhibition of the Renin Angiotensin System (RAS), vitamin D supplementation might boost the immune system of COVID-19 patients and reduce severity of the disease in vitamin D deficient individuals.
ISSN:1381-3455
1744-4160
DOI:10.1080/13813455.2020.1792505