Associations between early life stress and anterior pituitary gland volume development – A novel index of long‐term hypothalamic‐pituitary‐adrenal axis functioning

Previous research has established associations between early life stress (ELS) and altered pituitary gland volume (PGV) growth during adolescence. The pituitary gland, however, is composed of an anterior and a posterior lobe with distinct histological and neuroendocrinological properties. While the...

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Bibliographic Details
Published in:Developmental psychobiology 2021-05, Vol.63 (4), p.808-816
Main Authors: Díaz‐Arteche, Carmela, Simmons, Julian G., Ganella, Despina E., Schwartz, Orli, Kim, Jee Hyun, Farrow, Paige, Whittle, Sarah
Format: Article
Language:English
Subjects:
Adolescent
adolescent development
Adverse Childhood Experiences
Female
Humans
Hypothalamo-Hypophyseal System - physiology
Male
maternal behavior
neuroimaging
Pituitary Gland
Pituitary Gland, Anterior
Pituitary-Adrenal System - physiology
Stress, Psychological
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Summary:Previous research has established associations between early life stress (ELS) and altered pituitary gland volume (PGV) growth during adolescence. The pituitary gland, however, is composed of an anterior and a posterior lobe with distinct histological and neuroendocrinological properties. While the anterior (but not posterior) pituitary gland is directly involved in the hypothalamic‐pituitary‐adrenal axis (HPAA) stress response, no studies have examined the effects of ELS on anterior PGV (aPGV). The present study investigated whether previously reported associations between ELS and PGV development during adolescence were driven by aPGV versus posterior PGV (pPGV). Ninety‐one adolescents (49 males) were included from a longitudinal, community‐based adolescent development study investigating risk for psychopathology. ELS (maternal affective behavior, childhood maltreatment, stressful life events) was assessed during early adolescence. Participants underwent two waves of structural magnetic resonance imaging during mid‐ and late‐adolescence, and aPGV and pPGV were manually traced. Regression analyses showed that childhood maltreatment predicted greater aPGV growth in females. This finding was stronger than that previously reported for PGV. No associations were found between ELS and pPGV development. Neither aPGV nor pPGV changes mediated associations between ELS and psychopathology. Results suggest that ELS may accelerate aPGV (but not pPGV) growth throughout adolescence. Investigating the development of aPGV, rather than PGV, represents a novel approach to studying the effects of stress on HPAA functioning.
ISSN:0012-1630
1098-2302
DOI:10.1002/dev.22047