Epigenetic regulation of angiogenesis in lung cancer

Lung cancer is the leading cause of cancer‐related deaths worldwide, in which angiogenesis is highly required for lung cancer cell growth and metastasis. Genetic regulation of this multistep process is being studied extensively, however, relatively less is known about the epigenetic regulation of an...

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Bibliographic Details
Published in:Journal of cellular physiology 2021-05, Vol.236 (5), p.3194-3206
Main Authors: Tan, Heng Wee, Xu, Yan‐Ming, Qin, San‐Hai, Chen, Guo‐Feng, Lau, Andy T. Y.
Format: Article
Language:English
Subjects:
Angiogenesis
Deoxyribonucleic acid
DNA
DNA methylation
Epigenetics
Gene expression
histone modification
Histones
Lung cancer
Metastases
ncRNA expression
Regulations
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Summary:Lung cancer is the leading cause of cancer‐related deaths worldwide, in which angiogenesis is highly required for lung cancer cell growth and metastasis. Genetic regulation of this multistep process is being studied extensively, however, relatively less is known about the epigenetic regulation of angiogenesis in lung cancer. Several epigenetic alterations contribute to regulating angiogenesis, such as epimodifications of DNA, posttranslational modification of histones, and expression of noncoding RNAs. Here, we review the current knowledge of the epigenetic regulation of angiogenesis and discuss the potential clinical applications of epigenetic‐based anticancer therapy in lung cancer. Overall, epigenetic‐based therapy will likely emerge as a prominent approach to treat lung cancer in the future. Genetic regulation of angiogenesis is being studied extensively, however, relatively less is known about the epigenetic regulation of angiogenesis in lung cancer. Several epigenetic alterations contribute to regulating angiogenesis, such as epimodifications of DNA, posttranslational modification of histones, and expression of noncoding RNAs. Here, we review the current knowledge of the epigenetic regulation of angiogenesis and discuss the potential clinical applications of epigenetic‐based anticancer therapy in lung cancer.
ISSN:0021-9541
1097-4652
DOI:10.1002/jcp.30104