Effects of acute and sub-acute hypobaric hypoxia on oxidative stress: a field study in the Alps

Purpose High altitude results in lower barometric pressure and hence partial pressure of O 2 decrease can lead to several molecular and cellular changes, such as generation of reactive oxygen species (ROS). Electron Paramagnetic Resonance technique was adopted in the field, to evaluate the effects o...

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Bibliographic Details
Published in:European journal of applied physiology 2021, Vol.121 (1), p.297-306
Main Authors: Mrakic-Sposta, S., Gussoni, M., Dellanoce, C., Marzorati, M., Montorsi, M., Rasica, L., Pratali, L., D’Angelo, G., Martinelli, M., Bastiani, L., Di Natale, L., Vezzoli, A.
Format: Article
Language:English
Subjects:
Acclimatization
Altitude
Antioxidants
Biomarkers
Biomedical and Life Sciences
Biomedicine
Carbonyl compounds
Cytokines
Deoxyribonucleic acid
DNA
DNA damage
Electron spin resonance
Field study
High-altitude environments
Human Physiology
Hypoxia
Inflammation
Lipid peroxidation
Neopterin
Occupational Medicine/Industrial Medicine
Original Article
Oxidative stress
Reactive oxygen species
Renal function
Sports Medicine
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Summary:Purpose High altitude results in lower barometric pressure and hence partial pressure of O 2 decrease can lead to several molecular and cellular changes, such as generation of reactive oxygen species (ROS). Electron Paramagnetic Resonance technique was adopted in the field, to evaluate the effects of acute and sub-acute hypobaric hypoxia (HH) on ROS production by micro-invasive method. Biological biomarkers, indicators of oxidative stress, renal function and inflammation were investigated too. Methods Fourteen lowlander subjects (mean age 27.3 ± 5.9 years) were exposed to HH at 3269 m s.l. ROS production, related oxidative damage to cellular components, systemic inflammatory response and renal function were determined through blood and urine profile performed at 1st, 2nd, 4th, 7th, and 14th days during sojourn. Results Kinetics of changes during HH exposition showed out significant (range p  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-020-04527-x