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Embryo Selection Based on Morphological Parameters in a Single Vitrified-Warmed Blastocyst Transfer Cycle
The process of selecting a good quality embryo to improve the pregnancy outcomes is very important. The aim of our study was to elaborate the embryo selection process in a single vitrified-warmed blastocyst transfer (VBT) cycle by analyzing pre-vitrified and post-warmed blastocyst morphological fact...
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| Published in: | Reproductive sciences (Thousand Oaks, Calif.) Calif.), 2021-04, Vol.28 (4), p.1060-1068 |
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| cited_by | cdi_FETCH-LOGICAL-c347t-bb44c78f03c944262e866ce752ec4f2fb0dc64c65ebf840fb7e702c83ec5c2813 |
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| cites | cdi_FETCH-LOGICAL-c347t-bb44c78f03c944262e866ce752ec4f2fb0dc64c65ebf840fb7e702c83ec5c2813 |
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| container_title | Reproductive sciences (Thousand Oaks, Calif.) |
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| creator | Kim, Hyun Jin Park, Jae Kyun Eum, Jin Hee Song, Haengseok Lee, Woo Sik Lyu, Sang Woo |
| description | The process of selecting a good quality embryo to improve the pregnancy outcomes is very important. The aim of our study was to elaborate the embryo selection process in a single vitrified-warmed blastocyst transfer (VBT) cycle by analyzing pre-vitrified and post-warmed blastocyst morphological factors to improve pregnancy outcomes. In this retrospective cohort study, we performed 329 single VBT cycles. The pre-vitrified and post-warmed morphological factors of all blastocysts were analyzed. Logistic regression analysis was conducted to select the independent morphological factor associated with ongoing pregnancy. The expansion of blastocoel (mid blastocoel; aOR 2.27, 95% CI.0.80–6.42,
p
= 0.12, expanded blastocoel; aOR 3.15, 95% CI.1.18–8.44,
p
= 0.02) in a pre-vitrified blastocyst and the grade of inner cell mass (ICM) (grade B; aOR 0.47, 95% CI.0.27–0.83,
p
= 0.01, grade C; aOR 0.22, 95% CI 0.09–0.56
p
|
| doi_str_mv | 10.1007/s43032-020-00349-6 |
| format | article |
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p
= 0.12, expanded blastocoel; aOR 3.15, 95% CI.1.18–8.44,
p
= 0.02) in a pre-vitrified blastocyst and the grade of inner cell mass (ICM) (grade B; aOR 0.47, 95% CI.0.27–0.83,
p
= 0.01, grade C; aOR 0.22, 95% CI 0.09–0.56
p
< 0.01) in post-warmed blastocysts significantly predicted the ongoing pregnancy. After fertilization, the embryo developed as a blastocyst on day 5 (day 5) showed a higher ongoing pregnancy than that on day 6 (day 6) (aOR 0.50, 95% CI.0.26–0.94,
p
= 0.03). The results suggest that while selecting a vitrified-warmed blastocyst in a single VBT cycle, the day 5 vitrified blastocyst should be considered, and a higher expansion grade in the pre-vitrified blastocyst should be selected. Our study has shown that post-warmed ICM grade tends to be a predictive indicator for the selection of the best blastocyst and allows for successful pregnancy, with ongoing pregnancy in a single blastocyst transfer.</description><identifier>ISSN: 1933-7191</identifier><identifier>EISSN: 1933-7205</identifier><identifier>DOI: 10.1007/s43032-020-00349-6</identifier><identifier>PMID: 33051819</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Embryology ; Infertility: Original Article ; Medicine ; Medicine & Public Health ; Obstetrics/Perinatology/Midwifery ; Reproductive Medicine</subject><ispartof>Reproductive sciences (Thousand Oaks, Calif.), 2021-04, Vol.28 (4), p.1060-1068</ispartof><rights>Society for Reproductive Investigation 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-bb44c78f03c944262e866ce752ec4f2fb0dc64c65ebf840fb7e702c83ec5c2813</citedby><cites>FETCH-LOGICAL-c347t-bb44c78f03c944262e866ce752ec4f2fb0dc64c65ebf840fb7e702c83ec5c2813</cites><orcidid>0000-0001-5572-0898</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33051819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hyun Jin</creatorcontrib><creatorcontrib>Park, Jae Kyun</creatorcontrib><creatorcontrib>Eum, Jin Hee</creatorcontrib><creatorcontrib>Song, Haengseok</creatorcontrib><creatorcontrib>Lee, Woo Sik</creatorcontrib><creatorcontrib>Lyu, Sang Woo</creatorcontrib><title>Embryo Selection Based on Morphological Parameters in a Single Vitrified-Warmed Blastocyst Transfer Cycle</title><title>Reproductive sciences (Thousand Oaks, Calif.)</title><addtitle>Reprod. Sci</addtitle><addtitle>Reprod Sci</addtitle><description>The process of selecting a good quality embryo to improve the pregnancy outcomes is very important. The aim of our study was to elaborate the embryo selection process in a single vitrified-warmed blastocyst transfer (VBT) cycle by analyzing pre-vitrified and post-warmed blastocyst morphological factors to improve pregnancy outcomes. In this retrospective cohort study, we performed 329 single VBT cycles. The pre-vitrified and post-warmed morphological factors of all blastocysts were analyzed. Logistic regression analysis was conducted to select the independent morphological factor associated with ongoing pregnancy. The expansion of blastocoel (mid blastocoel; aOR 2.27, 95% CI.0.80–6.42,
p
= 0.12, expanded blastocoel; aOR 3.15, 95% CI.1.18–8.44,
p
= 0.02) in a pre-vitrified blastocyst and the grade of inner cell mass (ICM) (grade B; aOR 0.47, 95% CI.0.27–0.83,
p
= 0.01, grade C; aOR 0.22, 95% CI 0.09–0.56
p
< 0.01) in post-warmed blastocysts significantly predicted the ongoing pregnancy. After fertilization, the embryo developed as a blastocyst on day 5 (day 5) showed a higher ongoing pregnancy than that on day 6 (day 6) (aOR 0.50, 95% CI.0.26–0.94,
p
= 0.03). The results suggest that while selecting a vitrified-warmed blastocyst in a single VBT cycle, the day 5 vitrified blastocyst should be considered, and a higher expansion grade in the pre-vitrified blastocyst should be selected. Our study has shown that post-warmed ICM grade tends to be a predictive indicator for the selection of the best blastocyst and allows for successful pregnancy, with ongoing pregnancy in a single blastocyst transfer.</description><subject>Embryology</subject><subject>Infertility: Original Article</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Reproductive Medicine</subject><issn>1933-7191</issn><issn>1933-7205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kDlPAzEUhC0E4v4DFMglzcLzsVcJUTgkEEhcpeV1noORdx3sTZF_jyFASfVGejMjzUfIEYNTBlCfJSlA8AI4FABCtkW1QXZZK0RRcyg3fzVr2Q7ZS-kdoJQtb7bJjhBQsoa1u8RN-y6uAn1Ej2Z0YaAXOuGMZnEX4uIt-DB3Rnv6oKPuccSYqBuopo9umHukL26MzjqcFa869jl44XUag1mlkT5FPSSLkU5WxuMB2bLaJzz8ufvk-XL6NLkubu-vbibnt4URsh6LrpPS1I0FYVopecWxqSqDdcnRSMttBzNTSVOV2NlGgu1qrIGbRqApDW-Y2Ccn695FDB9LTKPqXTLovR4wLJPismRM8LpqspWvrSaGlCJatYiu13GlGKgvxGqNWGXE6huxqnLo-Kd_2eXBf5Ffptkg1oaUX8Mco3oPyzjkzf_VfgIWU4fE</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Kim, Hyun Jin</creator><creator>Park, Jae Kyun</creator><creator>Eum, Jin Hee</creator><creator>Song, Haengseok</creator><creator>Lee, Woo Sik</creator><creator>Lyu, Sang Woo</creator><general>Springer International Publishing</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5572-0898</orcidid></search><sort><creationdate>20210401</creationdate><title>Embryo Selection Based on Morphological Parameters in a Single Vitrified-Warmed Blastocyst Transfer Cycle</title><author>Kim, Hyun Jin ; Park, Jae Kyun ; Eum, Jin Hee ; Song, Haengseok ; Lee, Woo Sik ; Lyu, Sang Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-bb44c78f03c944262e866ce752ec4f2fb0dc64c65ebf840fb7e702c83ec5c2813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Embryology</topic><topic>Infertility: Original Article</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Reproductive Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hyun Jin</creatorcontrib><creatorcontrib>Park, Jae Kyun</creatorcontrib><creatorcontrib>Eum, Jin Hee</creatorcontrib><creatorcontrib>Song, Haengseok</creatorcontrib><creatorcontrib>Lee, Woo Sik</creatorcontrib><creatorcontrib>Lyu, Sang Woo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hyun Jin</au><au>Park, Jae Kyun</au><au>Eum, Jin Hee</au><au>Song, Haengseok</au><au>Lee, Woo Sik</au><au>Lyu, Sang Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Embryo Selection Based on Morphological Parameters in a Single Vitrified-Warmed Blastocyst Transfer Cycle</atitle><jtitle>Reproductive sciences (Thousand Oaks, Calif.)</jtitle><stitle>Reprod. Sci</stitle><addtitle>Reprod Sci</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>28</volume><issue>4</issue><spage>1060</spage><epage>1068</epage><pages>1060-1068</pages><issn>1933-7191</issn><eissn>1933-7205</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>The process of selecting a good quality embryo to improve the pregnancy outcomes is very important. The aim of our study was to elaborate the embryo selection process in a single vitrified-warmed blastocyst transfer (VBT) cycle by analyzing pre-vitrified and post-warmed blastocyst morphological factors to improve pregnancy outcomes. In this retrospective cohort study, we performed 329 single VBT cycles. The pre-vitrified and post-warmed morphological factors of all blastocysts were analyzed. Logistic regression analysis was conducted to select the independent morphological factor associated with ongoing pregnancy. The expansion of blastocoel (mid blastocoel; aOR 2.27, 95% CI.0.80–6.42,
p
= 0.12, expanded blastocoel; aOR 3.15, 95% CI.1.18–8.44,
p
= 0.02) in a pre-vitrified blastocyst and the grade of inner cell mass (ICM) (grade B; aOR 0.47, 95% CI.0.27–0.83,
p
= 0.01, grade C; aOR 0.22, 95% CI 0.09–0.56
p
< 0.01) in post-warmed blastocysts significantly predicted the ongoing pregnancy. After fertilization, the embryo developed as a blastocyst on day 5 (day 5) showed a higher ongoing pregnancy than that on day 6 (day 6) (aOR 0.50, 95% CI.0.26–0.94,
p
= 0.03). The results suggest that while selecting a vitrified-warmed blastocyst in a single VBT cycle, the day 5 vitrified blastocyst should be considered, and a higher expansion grade in the pre-vitrified blastocyst should be selected. Our study has shown that post-warmed ICM grade tends to be a predictive indicator for the selection of the best blastocyst and allows for successful pregnancy, with ongoing pregnancy in a single blastocyst transfer.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33051819</pmid><doi>10.1007/s43032-020-00349-6</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5572-0898</orcidid></addata></record> |
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| subjects | Embryology Infertility: Original Article Medicine Medicine & Public Health Obstetrics/Perinatology/Midwifery Reproductive Medicine |
| title | Embryo Selection Based on Morphological Parameters in a Single Vitrified-Warmed Blastocyst Transfer Cycle |
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