The targets of β-sitosterol as a novel therapeutic against cardio-renal complications in acute renal ischemia/reperfusion damage

This research is the first to use β-sitosterol on myocardial and renal tissues in renal ischemia/reperfusion (IR) damage. Female Wistar rats were randomly divided into three groups: control (sham), renal IR (50 min ischemia – 3 h reperfusion), and renal IR + 150 mg/kg/p.o. β-sitosterol (the rats wer...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 2021-03, Vol.394 (3), p.469-479
Main Authors: Koc, Kubra, Geyikoglu, Fatime, Cakmak, Ozge, Koca, Aynur, Kutlu, Zerrin, Aysin, Ferhunde, Yilmaz, Asli, Aşkın, Hakan
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Apoptosis
Apoptosis - drug effects
Biomedical and Life Sciences
Biomedicine
Female
Glutathione
Glutathione - metabolism
Hypolipidemic Agents - pharmacology
Hypolipidemic Agents - therapeutic use
Inflammation
Interleukin 6
Interleukin-6 - metabolism
Ischemia
Ischemia - drug therapy
Ischemia - metabolism
Ischemia - pathology
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Kidney Diseases - drug therapy
Kidney Diseases - metabolism
Kidney Diseases - pathology
Kidneys
Malondialdehyde
Malondialdehyde - metabolism
Myocardium - metabolism
Myocardium - pathology
Neurosciences
Nitric oxide
Nitric Oxide Synthase Type III - metabolism
Nitric-oxide synthase
Original Article
Oxidative stress
Pharmacology/Toxicology
Protective Agents - pharmacology
Protective Agents - therapeutic use
Rats
Rats, Wistar
Reperfusion
Reperfusion Injury - drug therapy
Reperfusion Injury - metabolism
Reperfusion Injury - pathology
Sitosterols - pharmacology
Sitosterols - therapeutic use
Superoxide dismutase
Superoxide Dismutase - metabolism
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-α
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Summary:This research is the first to use β-sitosterol on myocardial and renal tissues in renal ischemia/reperfusion (IR) damage. Female Wistar rats were randomly divided into three groups: control (sham), renal IR (50 min ischemia – 3 h reperfusion), and renal IR + 150 mg/kg/p.o. β-sitosterol (the rats were treated with β-sitosterol orally once 1 h before the IR procedure). β-Sitosterol pretreatment caused an increase in superoxide dismutase and glutathione activities and a decrease in malondialdehyde levels in the kidney and heart. Moreover, it alleviated histopathological changes and downregulated the levels of tumor necrosis factor-alpha and interleukin-6 and upregulated the levels of endothelial nitric oxide synthase. As conclusion, the potential of β-sitosterol for renal and cardiac necrosis and apoptosis appears to act by limiting inflammatory response and oxidative stress. Thus, the potential of this compound is noteworthy and may serve as a potential therapeutic in the treatment of acute organ damages due to renal IR.
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-020-01984-1