Near-infrared fluorescence imaging compared to standard sentinel lymph node detection with blue dye in patients with vulvar cancer – a randomized controlled trial

The aim of this study was to assess the superiority of ICG-99mTc-nanocolloid for the intraoperative visual detection of sentinel lymph nodes (SLNs) in vulvar squamous cell carcinoma (VSCC) patients compared to standard SLN detection using 99mTc-nanocolloid with blue dye. In this multicenter, randomi...

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Bibliographic Details
Published in:Gynecologic oncology 2020-12, Vol.159 (3), p.672-680
Main Authors: Deken, Marion M., van Doorn, Helena C., Verver, Danielle, Boogerd, Leonora S.F., de Valk, Kim S., Rietbergen, Daphne D.D., van Poelgeest, Mariëtte I.E., de Kroon, Cor D., Beltman, Jogchum J., van Leeuwen, Fijs W.B., Putter, Hein, Braak, Jeffrey P.B.M., de Geus-Oei, Lioe-Fee, van de Velde, Cock J.H., Burggraaf, Jacobus, Vahrmeijer, Alexander L., Gaarenstroom, Katja N.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - surgery
Coloring Agents - administration & dosage
Female
Humans
ICG-99mTc-nanocolloid
Indocyanine green
Intraoperative Care - methods
Lymph Node Excision
Lymphatic Metastasis - diagnosis
Lymphatic Metastasis - therapy
Middle Aged
Near-infrared fluorescence imaging
Netherlands
Operative Time
Optical Imaging - methods
Radiopharmaceuticals - administration & dosage
Randomized controlled trial
Sentinel lymph node
Sentinel Lymph Node - diagnostic imaging
Sentinel Lymph Node - pathology
Sentinel Lymph Node - surgery
Sentinel Lymph Node Biopsy - methods
Time Factors
Vulvar cancer
Vulvar Neoplasms - pathology
Vulvar Neoplasms - surgery
Vulvectomy
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Summary:The aim of this study was to assess the superiority of ICG-99mTc-nanocolloid for the intraoperative visual detection of sentinel lymph nodes (SLNs) in vulvar squamous cell carcinoma (VSCC) patients compared to standard SLN detection using 99mTc-nanocolloid with blue dye. In this multicenter, randomized controlled trial, VSCC patients underwent either the standard SLN procedure or with the hybrid tracer ICG-99mTc-nanocolloid. The primary endpoint was the percentage of fluorescent SLNs compared to blue SLNs. Secondary endpoints were successful SLN procedures, surgical outcomes and postoperative complications. Forty-eight patients were randomized to the standard (n = 24) or fluorescence imaging group (n = 24) using ICG-99mTc-nanocolloid. The percentage of blue SLNs was 65.3% compared to 92.5% fluorescent SLNs (p 
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2020.09.044