Thrombin generation in subjects with lupus anticoagulant without prior thrombosis or gestational morbidities

Lupus anticoagulant (LA) can be a cause of thrombosis and/or pregnancy morbidities, producing antiphospholipid syndrome (APS). An increase in thrombin generation (TG) is correlated with prothrombotic status. Several changes in TG-derived parameters have been reported in APS patients. Evaluate whethe...

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Published in:Thrombosis research 2020-12, Vol.196, p.425-431
Main Authors: Velasco-Rodríguez, Diego, Laso, Rosa Vidal, García-Raso, Aránzazu, Mahíllo-Fernández, Ignacio, Guzmán-López, Karina, Martín-Herrero, Sara, Barral, Elena Jiménez, Vegas-Sánchez, María del Carmen, Martínez-Becerra, María José, de la Plaza, Reyes, Romero, Luisa Fernanda López, Mínguez, Dolores, Alonso-Domínguez, Juan-Manuel, López, Carlos Blas, López, Amanda García, Fernández, M. Soledad Sánchez, Llamas-Sillero, Pilar
Format: Article
Language:English
Subjects:
Anti-β2GPI
Anticardiolipin
Antiphospholipid
Lupus anticoagulant
Thrombin generation
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Summary:Lupus anticoagulant (LA) can be a cause of thrombosis and/or pregnancy morbidities, producing antiphospholipid syndrome (APS). An increase in thrombin generation (TG) is correlated with prothrombotic status. Several changes in TG-derived parameters have been reported in APS patients. Evaluate whether the TG phenotype of APS can also be described in LA subjects without clinical manifestations of APS, and to investigate the possible influence of both LA potency and antiphospholipid (aPL) profile on it. TG was analyzed in 153 cases of LA and 41 healthy controls. We have observed prolongation of both lag time (3.7 min vs 2.32 min, p 
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2020.09.025