WUSCHEL triggers innate antiviral immunity in plant stem cells

Building a safe space for stem cells The meristem, the collection of stem cells that builds plants, is resistant to viral infection. Wu et al. now show that WUSCHEL, a transcription factor that helps to sustain stem cell production in the shoot apical meristem of Arabidopsis , also protects that ste...

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Published in:Science (American Association for the Advancement of Science) 2020-10, Vol.370 (6513), p.227-231
Main Authors: Wu, Haijun, Qu, Xiaoya, Dong, Zhicheng, Luo, Linjie, Shao, Chen, Forner, Joachim, Lohmann, Jan U., Su, Meng, Xu, Mengchu, Liu, Xiaobin, Zhu, Lei, Zeng, Jian, Liu, Sumei, Tian, Zhaoxia, Zhao, Zhong
Format: Article
Language:English
Subjects:
Arabidopsis
Immunity
Infections
Meristems
Methionine
Organs
Plant cells
Plant virus diseases
Protein biosynthesis
Protein synthesis
Proteins
RNA processing
rRNA
Stability
Stem cells
Viral infections
Viruses
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Summary:Building a safe space for stem cells The meristem, the collection of stem cells that builds plants, is resistant to viral infection. Wu et al. now show that WUSCHEL, a transcription factor that helps to sustain stem cell production in the shoot apical meristem of Arabidopsis , also protects that stem cell domain from viruses. WUSCHEL inhibited viral protein synthesis by repressing methyltransferases that regulate ribosomal RNA processing and ribosome stability. Science , this issue p. 227 Manipulation of protein synthesis restricts viral invasion in stem cells of the Arabidopsis shoot apical meristem. Stem cells in plants constantly supply daughter cells to form new organs and are expected to safeguard the integrity of the cells from biological invasion. Here, we show how stem cells of the Arabidopsis shoot apical meristem and their nascent daughter cells suppress infection by cucumber mosaic virus (CMV). The stem cell regulator WUSCHEL responds to CMV infection and represses virus accumulation in the meristem central and peripheral zones. WUSCHEL inhibits viral protein synthesis by repressing the expression of plant S -adenosyl- l -methionine–dependent methyltransferases, which are involved in ribosomal RNA processing and ribosome stability. Our results reveal a conserved strategy in plants to protect stem cells against viral intrusion and provide a molecular basis for WUSCHEL-mediated broad-spectrum innate antiviral immunity in plants.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.abb7360