Could the performance of oral glucose tolerance test contribute to the brain health-focused care in multiple sclerosis?

•The prevalence of insulin resistance in MS patients is higher than in controls.•MS patients have significantly higher risk of impaired glucose metabolism.•Glucose level at 120′ during OGTT is independently associated with MS.•EDSS and disability progression are associated with glucose levels during...

Full description

Saved in:
Bibliographic Details
Published in:Multiple sclerosis and related disorders 2020-11, Vol.46, p.102536-102536, Article 102536
Main Authors: Maric, Gorica, Lalic, Katarina, Pekmezovic, Tatjana, Tamas, Olivera, Rajkovic, Natasa, Rasulic, Iva, Mesaros, Sarlota, Drulovic, Jelena
Format: Article
Language:English
Subjects:
Blood Glucose
Body Mass Index
Brain
Glucose Tolerance Test
Humans
Insulin
Insulin Resistance
Multiple sclerosis
Multiple Sclerosis - diagnosis
Multiple Sclerosis - epidemiology
oral glucose tolerance test (OGTT)
type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•The prevalence of insulin resistance in MS patients is higher than in controls.•MS patients have significantly higher risk of impaired glucose metabolism.•Glucose level at 120′ during OGTT is independently associated with MS.•EDSS and disability progression are associated with glucose levels during OGTT. It has not been clarified yet if persons with multiple sclerosis (MS) are at increased risk to develop glucose metabolism dysregulation. The aims of the present study were to evaluate glucose metabolism characteristics in persons with MS and to compare it to the healthy individuals; to examine the association of glucose metabolism with the level of disability and its progression. The study enrolled 78 patients with MS and 26, comparable for age, gender and body mass index (BMI), healthy controls (HC). Disability and its progression were evaluated by the Expanded Disability Status Scale (EDSS) score, progression index (PI) and multiple sclerosis severity score (MSSS). All participants performed an oral glucose tolerance test (OGTT). Insulin and lipid parameters were analyzed. Fasting glucose concentrations (5.3±0.7 in MS patients vs. 4.5±0.9 mmol/L in HC, p=0.001) and 2 hour post-load glucose concentrations were statistically significantly higher in MS patients compared with controls. Glucose levels at all different time points during OGTT, baseline insulin, Homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol and LDL were statistically significantly (p
ISSN:2211-0348
2211-0356
DOI:10.1016/j.msard.2020.102536