Patients with acromegaly might not be at higher risk for dopamine agonist-induced impulse control disorders than those with prolactinomas

To evaluate the prevalence of impulse control disorders (ICD) and psychiatric symptoms in patients with acromegaly receiving dopamine agonists (DA) in comparison with those with prolactinoma, nonfunctioning pituitary adenomas (NFA), and healthy controls (HC). Forty patients with acromegaly, 40 with...

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Bibliographic Details
Published in:Growth hormone & IGF research 2020-12, Vol.55, p.101356-101356, Article 101356
Main Authors: Ozkaya, Hande Mefkure, Sahin, Serdar, Korkmaz, Ozge Polat, Durcan, Emre, Sahin, Humeyra Rekali, Celik, Emir, Poyraz, Burc Cagri, Kadioglu, Pinar
Format: Article
Language:English
Subjects:
Acromegaly
Dopamine agonist
Impulse control disorder
Prevalence
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Summary:To evaluate the prevalence of impulse control disorders (ICD) and psychiatric symptoms in patients with acromegaly receiving dopamine agonists (DA) in comparison with those with prolactinoma, nonfunctioning pituitary adenomas (NFA), and healthy controls (HC). Forty patients with acromegaly, 40 with prolactinoma, 38 with NFA, and 32 HCs were included. All patients and controls were evaluated using the revised version of the Minnesota Impulsive Disorders Interview (MIDI-R), Symptom Check List (SCL-90-R) questionnaire, Barratt Impulsiveness Scale (BIS-11), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI). We detected ICD associated with DAs in two patients with acromegaly (5%) and three patients (7.5%) with prolactinoma. All patients' symptoms resolved after discontinuation of the drug. While the mean DA dose was higher in patients with acromegaly than prolactinomas (p  0.05). SCL-90 depression and interpersonal sensitivity subscale positivity was higher in patients with NFA than HCs. Patients with prolactinoma had higher obsession and interpersonal sensitivity positivity and those with NFA had higher somatization, interpersonal sensitivity, and depression positivity as compared to patients with acromegaly (p 
ISSN:1096-6374
1532-2238
DOI:10.1016/j.ghir.2020.101356