Functional correlations between CXCL10/IP10 gene polymorphisms and risk of Kawasaki disease

Background Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T‐cell activation. The aim of this study was to investigate the association between gen...

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Bibliographic Details
Published in:Pediatric allergy and immunology 2021-02, Vol.32 (2), p.363-370
Main Authors: Hsu, Yu‐Wen, Lu, Hsing‐Fang, Chou, Wan‐Hsuan, Kuo, Ho‐Chang, Chang, Wei‐Chiao, Atanaskovic‐Markovic, Marina
Format: Article
Language:English
Subjects:
Case-Control Studies
Cell activation
Chemokine CXCL10 - genetics
CXCL10
CXCL10 protein
Gene Frequency
Gene polymorphism
Genetic Predisposition to Disease
Genotype
Genotype & phenotype
Genotyping
Haplotypes
Humans
Immune system
in silico analysis
IP10
Kawasaki disease
Mucocutaneous lymph node syndrome
Mucocutaneous Lymph Node Syndrome - genetics
Polymorphism, Single Nucleotide
Single-nucleotide polymorphism
SNP association study
Systemic vasculitis
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Summary:Background Kawasaki disease (KD) is an acute systemic vasculitis syndrome with unknown pathogen. The immune system has been suggested to involve in the pathogenesis in KD. IP10 is a chemoattractant for initiating T‐cell activation. The aim of this study was to investigate the association between genetic polymorphisms of IP10 and KD. Methods A total of 354 KD patients and 1,709 control subjects (709 subjects in cohort 1 and 1,000 subjects in cohort 2) were enrolled in this study. Four tagging single nucleotide polymorphisms (rs3921, rs4256246, rs4508917, and rs4386624) were chosen for genotyping. Results Our results indicated that CC genotype of rs3921 and GG genotype of rs4386624 had higher frequency in KD patients compared to control. In addition, higher plasma IP10 level was observed in CC genotype of rs3921 than CG genotype and GG genotype. C/G haplotype carriers of rs3921/rs4386624 had 5.48‐fold risk for KD compared to G/C haplotype carriers. Two‐locus analysis further showed the combinatorial effects of rs3921 and rs4386624 in KD susceptibility. Conclusions This study indicated the close correlation between IP10 and the risk of Kawasaki disease.
ISSN:0905-6157
1399-3038
DOI:10.1111/pai.13381