Lung ultrasound score and diuretics in preterm infants born before 32 weeks: A pilot study

Objective To describe if weekly determined lung ultrasound (LU) scores in preterm infants born before 32 weeks (PTB32W) change with diuretic therapy. Design We included infants who received diuretics and compared LU scores according to their evolution on respiratory support (RS) before and after diu...

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Bibliographic Details
Published in:Pediatric pulmonology 2020-12, Vol.55 (12), p.3312-3318
Main Authors: Alonso‐Ojembarrena, Almudena, Lechuga‐Sancho, Alfonso María, Morales‐Arandojo, Patricia, Acuñas‐Soto, Silvia, López‐de‐Francisco, Rosa, Lubián‐López, Simón Pedro
Format: Article
Language:English
Subjects:
bronchopulmonary dysplasia
Bronchopulmonary Dysplasia - diagnostic imaging
Bronchopulmonary Dysplasia - therapy
Diuretics
Diuretics - therapeutic use
Female
Gestational Age
Humans
Infant
Infant, Newborn
Infant, Premature
Lung - diagnostic imaging
Lung - drug effects
Lungs
Male
Neonatal care
neonatal intensive care unit
Pilot Projects
Premature babies
Respiration, Artificial
Ultrasonic imaging
Ultrasonography
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Summary:Objective To describe if weekly determined lung ultrasound (LU) scores in preterm infants born before 32 weeks (PTB32W) change with diuretic therapy. Design We included infants who received diuretics and compared LU scores according to their evolution on respiratory support (RS) before and after diuretics. Results We included 18 PTB32W divided into two groups. Both groups were similar in terms of median gestational age: 26 weeks (interquartile range [IQR]: 25–28) in the responders' group and 27 weeks (IQR: 24–28) in the other. They differed, however, in the median number of days on invasive mechanical ventilation: 27 (IQR: 11–43) versus 76 (IQR: 35–117), p = .03; in addition to the number of infants with moderate‐severe bronchopulmonary dysplasia: 3 (33%) versus 8 (89%), p = .025. The responders' group showed lower LU scores 2 days after diuretics, with a median LU score of 6 (IQR: 3–12) versus 14 (IQR: 12–17) in the nonresponders group, p = .03; 1 week after (3 [IQR: 0–10] versus 12 [12–12], p = .04); and 3 weeks after (5 [IQR: 3–6] versus 12 [10–15], p = .01). RS also decreased at the same time: 7 out of 9 (78%) were extubated in the responders' group, and 1 out of 9 (11%) in the nonresponders group, p = .02, and these differences remained throughout the entire follow‐up. Conclusions There is a group of PTB32W patients whose LU score improves after diuretics. This change appears only in those patients that can be weaned off from RS, and at the same period of time as the administration of diuretics.
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.25098