Angioscopic Assessments at 3 Months After Fluoropolymer-Based Paclitaxel-Eluting Stent Implantation for Femoropopliteal Endovascular Intervention

Background:The detailed mechanism of early-phase arterial healing after novel fluoropolymer-based paclitaxel-eluting stent (PES) implantation in the femoropopliteal (FP) lesions has not been elucidated.Methods and Results:We evaluated the intravascular status of 20 PES implanted in 11 FP lesions of...

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Published in:Circulation Journal 2020/10/23, Vol.84(11), pp.1999-2005
Main Authors: Tsujimura, Takuya, Ishihara, Takayuki, Iida, Osamu, Hata, Yosuke, Kurata, Naoya, Asai, Mitsutoshi, Masuda, Masaharu, Okamoto, Shin, Nanto, Kiyonori, Kanda, Takashi, Matsuda, Yasuhiro, Mano, Toshiaki
Format: Article
Language:English
Subjects:
Angioscopy
Drug-eluting stents
Endovascular therapy
Peripheral artery disease
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Summary:Background:The detailed mechanism of early-phase arterial healing after novel fluoropolymer-based paclitaxel-eluting stent (PES) implantation in the femoropopliteal (FP) lesions has not been elucidated.Methods and Results:We evaluated the intravascular status of 20 PES implanted in 11 FP lesions of 9 patients using angioscopy at approximately 3 months after implantation. Angioscopic images were analyzed to determine (1) the dominant degree of neointimal coverage (NIC) over the stent; (2) the extent of uncovered struts; and (3) the presence of intrastent thrombus. NIC was classified into 4 grades: grade 0, stent struts fully visible; grade 1, stent struts bulging into the lumen although covered; grade 2, stent struts embedded in neointima, but translucently visible; grade 3, stent struts fully embedded and invisible. The extent of uncovered struts was scored as follows: score 0, no uncovered struts of the entire stent; score 1, uncovered struts area approximately
ISSN:1346-9843
1347-4820
DOI:10.1253/circj.CJ-20-0551