Association of ABCG1 gene methylation and its dynamic change status with incident type 2 diabetes mellitus: the Rural Chinese Cohort Study

To explore whether DNA methylation of the ATP-binding cassette G1 (ABCG1) gene and its dynamic change are associated with incident type 2 diabetes mellitus (T2DM). We conducted a nested case-control study with 286 pairs of T2DM cases and matched controls nested in the Rural Chinese Cohort Study. Con...

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Published in:Journal of human genetics 2021-04, Vol.66 (4), p.347-357
Main Authors: Qie, Ranran, Chen, Qing, Wang, Tieqiang, Chen, Xiaoliang, Wang, Jian, Cheng, Ruirong, Lin, Jinchun, Zhao, Yang, Liu, Dechen, Qin, Pei, Cheng, Cheng, Liu, Leilei, Li, Quanman, Guo, Chunmei, Zhou, Qionggui, Tian, Gang, Han, Minghui, Huang, Shengbing, Zhang, Yanyan, Wu, Xiaoyan, Wu, Yuying, Li, Yang, Yang, Xingjin, Feng, Yifei, Hu, Dongsheng, Zhang, Ming
Format: Article
Language:English
Subjects:
ABCG1 gene
Body mass index
Cohort analysis
Deoxyribonucleic acid
Diabetes
Diabetes mellitus (non-insulin dependent)
DNA
DNA methylation
Regression analysis
Risk factors
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Summary:To explore whether DNA methylation of the ATP-binding cassette G1 (ABCG1) gene and its dynamic change are associated with incident type 2 diabetes mellitus (T2DM). We conducted a nested case-control study with 286 pairs of T2DM cases and matched controls nested in the Rural Chinese Cohort Study. Conditional logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for incident T2DM risk according to ABCG1 methylation level at baseline and its dynamic change at follow-up examination. Spearman's rank correlation coefficients were used to analyze the association between ABCG1 methylation and its possible risk factors in the control group. We found that T2DM risk increased by 16% (OR = 1.16, 95% CI = 1.02-1.31) with each 1% increase in DNA methylation levels of the ABCG1 loci CpG13 and CpG14. DNA methylation change of the ABCG1 locus CpG15 during the 6-year follow-up was associated with increased T2DM risk: T2DM risk increased by 78% in the upper tertile group (methylation gain ≥5%) versus lower tertile group (methylation gain
ISSN:1434-5161
1435-232X
DOI:10.1038/s10038-020-00848-z