Association of preoperative serum De Ritis ratio with oncological outcomes in patients treated with cytoreductive nephrectomy for metastatic renal cell carcinoma

•We tested the association between preoperative serum De Ritis ratio (DRR, Aspartate Aminotransferase/Alanine Aminotransferase) and overall survival as well as cancer-specific survival in 613 mRCC patients treated with cytoreductive nephrectomy.•We found an independent association of DRR ≥1.2 with u...

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Published in:Urologic oncology 2020-12, Vol.38 (12), p.936.e7-936.e14
Main Authors: Laukhtina, Ekaterina, Pradere, Benjamin, D`Andrea, David, Rosiello, Giuseppe, Luzzago, Stefano, Pecoraro, Angela, Palumbo, Carlotta, Knipper, Sophie, Karakiewicz, Pierre I., Margulis, Vitaly, Quhal, Fahad, Sari Motlagh, Reza, Mostafaei, Hadi, Mori, Keiichiro, Kimura, Shoji, Enikeev, Dmitry, Shariat, Shahrokh F.
Format: Article
Language:English
Subjects:
CSS
Cytoreductive nephrectomy
De Ritis ratio
mRCC
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Summary:•We tested the association between preoperative serum De Ritis ratio (DRR, Aspartate Aminotransferase/Alanine Aminotransferase) and overall survival as well as cancer-specific survival in 613 mRCC patients treated with cytoreductive nephrectomy.•We found an independent association of DRR ≥1.2 with unfavorable clinical outcomes.•The addition of DRR only minimally improved the discrimination of a base model that included established clinicopathologic features. Identifying which patients are likely to benefit from cytoreductive nephrectomy (CN) for metastatic renal cell carcinoma (mRCC) is important. We tested the association between preoperative serum De Ritis ratio (DRR, Aspartate Aminotransferase/Alanine Aminotransferase) and overall survival (OS) as well as cancer-specific survival (CSS) in mRCC patients treated with CN. mRCC patients treated with CN at different institutions were included. After assessing for the optimal pretreatment DRR cut‐off value, we found 1.2 to have the maximum Youden index value. The overall population was therefore divided into 2 DRR groups using this cut‐off (low,
ISSN:1078-1439
1873-2496
DOI:10.1016/j.urolonc.2020.08.013