Innate Immune Mechanisms of Arterial Hypertension and Autoimmune Disease

Abstract The immune system is indispensable in the development of vascular dysfunction and hypertension. The interplay between immune cells and the vasculature, kidneys, heart, and blood pressure regulating nuclei in the central nervous system results in a complex and closely interwoven relationship...

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Bibliographic Details
Published in:American journal of hypertension 2021-03, Vol.34 (2), p.143-153
Main Authors: Jung, Rebecca, Wild, Johannes, Ringen, Julia, Karbach, Susanne, Wenzel, Philip
Format: Article
Language:English
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Summary:Abstract The immune system is indispensable in the development of vascular dysfunction and hypertension. The interplay between immune cells and the vasculature, kidneys, heart, and blood pressure regulating nuclei in the central nervous system results in a complex and closely interwoven relationship of the immune system with arterial hypertension. A better understanding of this interplay is necessary for optimized and individualized antihypertensive therapy. Our review article focuses on innate cells in hypertension and to what extent they impact on development and preservation of elevated blood pressure. Moreover, we address the association of hypertension with chronic autoimmune diseases. The latter are ideally suited to learn about immune-mediated mechanisms in cardiovascular disease leading to high blood pressure.
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1093/ajh/hpaa145