Effects of brown seaweeds on postprandial glucose, insulin and appetite in humans – A randomized, 3-way, blinded, cross-over meal study

Seaweed including brown seaweeds with rich bioactive components may be efficacious for a glycaemic management strategy and appetite control. We investigated the effects of two brown edible seaweeds, Laminaria digitata (LD) and Undaria pinnatifida (UP), on postprandial glucose metabolism and appetite...

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Published in:Clinical nutrition (Edinburgh, Scotland) Scotland), 2021-03, Vol.40 (3), p.830-838
Main Authors: Zaharudin, Nazikussabah, Tullin, Mikkel, Pekmez, Ceyda Tugba, Sloth, Jens J., Rasmussen, Rie R., Dragsted, Lars O.
Format: Article
Language:English
Subjects:
Adult
Alpha-glucosidase
Appetite
Bioactive foods
Blood Glucose - analysis
C-Peptide - blood
Cross-Over Studies
Diet
Dietary Carbohydrates - administration & dosage
Female
Glucagon-Like Peptide 1 - blood
Glycaemic response
Humans
Insulin - blood
Laminaria
Male
Meals
Middle Aged
Phaeophyceae
Postprandial Period
Resistant dietary fibers
Satiety
Seaweed
Starch
Starch-degrading enzymes
Undaria
Young Adult
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Summary:Seaweed including brown seaweeds with rich bioactive components may be efficacious for a glycaemic management strategy and appetite control. We investigated the effects of two brown edible seaweeds, Laminaria digitata (LD) and Undaria pinnatifida (UP), on postprandial glucose metabolism and appetite following a starch load in a human meal study. Twenty healthy subjects were enrolled in a randomized, 3-way, blinded cross-over trial. The study was registered under ClinicalTrials.gov Identifier no. NCT00123456. At each test day, the subjects received one of three meals comprising 30 g of starch with 5 g of LD or UP or an energy-adjusted control meal containing pea protein. Fasting and postprandial blood glucose, insulin, C-peptide and glucagon-like peptide-1 (GLP-1) concentrations were measured. Subjective appetite sensations were scored using visual analogue scales (VAS). Linear mixed model (LMM) analysis showed a lower blood glucose, insulin and C-peptide response following the intake of LD and UP, after correction for body weight. Participants weighing ≤ 63 kg had a reduced glucose response compared to control meal between 40 and 90 min both following LD and UP meals. Furthermore, LMM analysis for C-peptide showed a significantly lower response after intake of LD. Compared to the control meal, GLP-1 response was higher after the LD meal, both before and after the body weight adjustment. The VAS scores showed a decreased appetite sensation after intake of the seaweeds. Ad-libitum food intake was not different three hours after the seaweed meals compared to control. Concomitant ingestion of brown seaweeds may help improving postprandial glycaemic and appetite control in healthy and normal weight adults, depending on the dose per body weight. Clinicaltrials.gov (ID# NCT02608372).
ISSN:0261-5614
1532-1983
DOI:10.1016/j.clnu.2020.08.027