Early indicators of primary brain tumours: a population‐based study with 10 years’ follow‐up

Background and purpose To improve diagnoses of primary brain tumours, knowledge about early indicators is needed. Nationwide Danish health registries were used to conduct a population‐based case–control study including all persons diagnosed with a primary brain tumour between 2005 and 2014 in Denmar...

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Bibliographic Details
Published in:European journal of neurology 2021-01, Vol.28 (1), p.278-285
Main Authors: Marku, M., Rasmussen, B. K., Dalton, S. O., Johansen, C., Hamerlik, P., Andersen, K. K., Meier, S. M., Bidstrup, P. E.
Format: Article
Language:English
Subjects:
adult
Brain
Brain cancer
Brain tumors
case–control study
Confidence intervals
Diagnosis
Disorders
Epilepsy
Indicators
Nervous system
Nervous system diseases
Neurological disorders
oncology
Population studies
Population-based studies
primary brain tumour
Regression analysis
risk factors
Statistical analysis
Tumors
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Summary:Background and purpose To improve diagnoses of primary brain tumours, knowledge about early indicators is needed. Nationwide Danish health registries were used to conduct a population‐based case–control study including all persons diagnosed with a primary brain tumour between 2005 and 2014 in Denmark. Methods All 5135 adults diagnosed with a primary brain tumour in the Danish Cancer Registry were matched to 19 572 general population comparisons from the Danish Civil Registration System. Conditional logistic regression analyses were applied to estimate age‐ and multivariable‐adjusted odds ratios (ORs) for the occurrence of a primary brain tumour up to 10 years after hospital diagnoses or prescription of medications related to nervous system diseases and mental and behavioural disorders. Results Increased odds for primary brain tumour after nervous system diseases and mental and behavioural disorders manifested up to 10 years before tumour diagnosis were found. Increased odds were seen especially for hospital contacts for inflammatory nervous system diseases [OR 11.3; 95% confidence interval (CI) 6.5–19.7], epilepsy (OR 9.0; 95% CI 7.6–10.7) and antiepileptic medications (OR 3.6; 95% CI 3.2–4.0), whilst antidementia medications provided a strong, protective association for primary brain tumours (OR 0.5; 95% CI 0.3–0.8). Conclusions Sub‐groups of patients diagnosed with or being prescribed certain medications targeting nervous system diseases and mental and behavioural disorders may be at increased risk of being diagnosed with a primary brain tumour. Further studies should disentangle the potential underlying common pathogenetic pathways. The results are important for the development of systematic clinical approaches to ensure early diagnosis of primary brain tumours. We used nationwide Danish health registries with information on hospitalization and prescription medication to examine the association between nervous system diseases and mental and behavioral disorders and risk for primary brain tumor. We found increased odds for a primary brain tumor after a number of nervous system diseases as well as mental and behavioral disorders, especially inflammatory diseases of the nervous system and epilepsy, suggesting the importance of early detection of primary brain tumors.
ISSN:1351-5101
1468-1331
DOI:10.1111/ene.14527