The Effect of Emergency Department Visits and Inflammatory Markers on One-Year Mortality in Patients with Heart Failure

The neurohumoral and inflammatory pathways proposed for the development and progression of heart failure (HF) remain up-to-date. We aimed to investigate the effect of emergency department (ED) visits and inflammatory markers on mortality in HF patients. Two-hundred patients with stable chronic HF fo...

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Bibliographic Details
Published in:Cardiovascular toxicology 2021, Vol.21 (1), p.49-58
Main Authors: Köse, Ataman, Çelik, Ahmet, Altınsoy, Ersin, Bozkurt Babus, Seyran, Erdoğan, Semra
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cardiac patients
Cardiology
Congestive heart failure
Emergency medical care
Emergency medical services
Emergency service
Heart failure
Hospitals
Immunoglobulins
Inflammation
Markers
Medical research
Medicine, Experimental
Mortality
Patient outcomes
Pharmacology/Toxicology
Risk
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Summary:The neurohumoral and inflammatory pathways proposed for the development and progression of heart failure (HF) remain up-to-date. We aimed to investigate the effect of emergency department (ED) visits and inflammatory markers on mortality in HF patients. Two-hundred patients with stable chronic HF followed by the cardiology clinic were included in this study. The patients were divided into two groups as patients who had visited the ED due to worsening HF symptoms within the last 6 months (ED visit Group) and who had not (No ED visit Group). The demographical properties, clinical characteristics, and laboratory values including inflammatory markers of the patients were recorded. During the follow-up period, 38 patients (19%) died. In HF patients with previous ED visits, the mortality risk was 2.091 times higher (relative risk, RR). It was identified that the HF patients who died during the follow-up had higher initial NLR ( p  = 0.004), IG% ( p  = 0.029), hs-CRP ( p  = 0.001), and NT-proBNP ( p  = 0.004) values. It was observed that the area under the curve (AUC) values, NLR (AUC: 0.705, p   0.4 (95% CI 1.16–4.957), and 4,2 times higher when hs-CRP > 9.9 mg/dl (95% CI 2.16–8.16) ( p  
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-020-09594-2