Lower Level of Plasma 25-Hydroxyvitamin D in Children at Diagnosis of Celiac Disease Compared with Healthy Subjects: A Case-Control Study

To evaluate the vitamin D status of children with a new diagnosis of celiac disease compared with healthy controls. This was a case-control study. Cases were consecutive children with newly diagnosed celiac disease. Controls were healthy children matched for age, sex, ethnicity, and month of blood t...

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Bibliographic Details
Published in:The Journal of pediatrics 2021-01, Vol.228, p.132-137.e1
Main Authors: Lionetti, Elena, Galeazzi, Tiziana, Dominijanni, Vera, Acquaviva, Ilaria, Catassi, Giulia N., Iasevoli, Mario, Malamisura, Basilio, Catassi, Carlo
Format: Article
Language:English
Subjects:
Case-Control Studies
Celiac Disease - blood
Celiac Disease - complications
Celiac Disease - diagnosis
Child
Child, Preschool
controls
deficiency
Female
Humans
Male
Nutritional Status
pediatric celiac disease
Risk Factors
Seasons
vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - etiology
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Summary:To evaluate the vitamin D status of children with a new diagnosis of celiac disease compared with healthy controls. This was a case-control study. Cases were consecutive children with newly diagnosed celiac disease. Controls were healthy children matched for age, sex, ethnicity, and month of blood testing. Plasma 25-hydroxyvitamin D (25-OHD) was measured as the index of vitamin D nutritional status. The Student t test was used for comparisons. Differences in frequencies were evaluated with the χ2 test. Associations between variables were estimated by calculating Pearson correlation coefficients. There were 131 children with celiac disease enrolled (62% females; mean age 8.1 ± 1.1 years). The control group included 131 healthy children (62% females; mean age 8.2 ± 1.2). All were of European origin. Plasma 25-OHD levels were significantly lower in patients than in controls (25.3 ± 8.0 and 31.6 ± 13.7 ng/mL; P 
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2020.08.089