Chemical constituents and dereplication study of Lessingianthus brevifolius (Less.) H.Rob. (Asteraceae) by UHPLC-HRMS and molecular networking

Chemical investigation of (Less.) H.Rob. aerial parts resulted in the isolation of the hirsutinolide-type sesquiterpene lactones piptocarphol, spicatolide D, piptocarphin D and 8α-acetoxy-10α-hydroxy-13- -methylhirsutinolide, and also of a cadinanolide identified as 13- -methylvernojalcanolide 8- -a...

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Published in:Natural product research 2022-04, Vol.36 (7), p.1889-1892
Main Authors: Arêas, Drielli Rhiane P Colhado, Cabral, Márcia R P, Ramos, Anderson V G, Peixoto, Juliana L B, do Carmo, Marta R Barrotto, Baldoqui, Debora C, Porto, Carla, Sarragiotto, Maria Helena
Format: Article
Language:English
Subjects:
Asteraceae - chemistry
Chromatography, High Pressure Liquid
Lactones - chemistry
Plant Components, Aerial - chemistry
Sesquiterpenes - chemistry
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Summary:Chemical investigation of (Less.) H.Rob. aerial parts resulted in the isolation of the hirsutinolide-type sesquiterpene lactones piptocarphol, spicatolide D, piptocarphin D and 8α-acetoxy-10α-hydroxy-13- -methylhirsutinolide, and also of a cadinanolide identified as 13- -methylvernojalcanolide 8- -acetate. Flavonoids, triterpenes and chlorogenic acids were also isolated. In addition, a dereplication study was carried out using UHPLC-HRMS and molecular networking, resulting in the identification of fifteen known compounds, being two sesquiterpene lactones and thirteen flavonoids. Some of the compounds are being described for the first time in and also in the genus.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2020.1813132