Photoreactive Carboxybetaine Copolymers Impart Biocompatibility and Inhibit Plasticizer Leaching on Polyvinyl Chloride

Protein and cell interactions on implanted, blood-contacting medical device surfaces can lead to adverse biological reactions. Medical-grade poly­(vinyl chloride) (PVC) materials have been used for decades, particularly as blood-contacting tubes and containers. However, there are numerous concerns w...

Full description

Saved in:
Bibliographic Details
Published in:ACS applied materials & interfaces 2020-09, Vol.12 (37), p.41026-41037
Main Authors: Lin, Xiaojie, Wu, Kan, Zhou, Qiong, Jain, Priyesh, Boit, Mary O’Kelly, Li, Bowen, Hung, Hsiang-Chieh, Creason, Sharon A, Himmelfarb, Jonathan, Ratner, Buddy D, Jiang, Shaoyi
Format: Article
Language:English
Subjects:
Adsorption
Animals
Biocompatible Materials - chemistry
Biological and Medical Applications of Materials and Interfaces
Mice
Molecular Structure
NIH 3T3 Cells
Particle Size
Photochemical Processes
Plasticizers - chemistry
Polymers - chemical synthesis
Polymers - chemistry
Surface Properties
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Protein and cell interactions on implanted, blood-contacting medical device surfaces can lead to adverse biological reactions. Medical-grade poly­(vinyl chloride) (PVC) materials have been used for decades, particularly as blood-contacting tubes and containers. However, there are numerous concerns with their performance including platelet activation, complement activation, and thrombin generation and also leaching of plasticizers, particularly in clinical applications. Here, we report a surface modification method that can dramatically prevent blood protein adsorption, human platelet activation, and complement activation on commercial medical-grade PVC materials under various test conditions. The surface modification can be accomplished through simple dip-coating followed by light illumination utilizing biocompatible polymers comprising zwitterionic carboxybetaine (CB) moieties and photosensitive cross-linking moieties. This surface treatment can be manufactured routinely at small or large scales and can impart to commercial PVC materials superhydrophilicity and nonfouling capability. Furthermore, the polymer effectively prevented leaching of plasticizers out from commercial medical-grade PVC materials. This coating technique is readily applicable to many other polymers and medical devices requiring surfaces that will enhance performance in clinical settings.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.0c09457