Analysis of plasma protein biomarkers in childhood onset multiple sclerosis

Multiple sclerosis (MS) manifesting before age 18 years is defined as pediatric MS (pMS). We analysed plasma proteins in pMS by an untargeted proteomic approach. Patients with pMS (Group pMS, n = 33), patients with demyelinating disease not meeting pMS diagnostic criteria (unclassified demyelinating...

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Bibliographic Details
Published in:Journal of neuroimmunology 2020-11, Vol.348, p.577359-577359, Article 577359
Main Authors: Solmaz, Ismail, Kocak, Engin, Kaplan, Ozan, Celebier, Mustafa, Anlar, Banu
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Biomarker
Biomarkers - blood
Blood Proteins - analysis
Child
Female
Humans
Male
Multiple sclerosis
Multiple Sclerosis - blood
Multiple Sclerosis - diagnosis
Pediatric
Proteomics
Young Adult
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Summary:Multiple sclerosis (MS) manifesting before age 18 years is defined as pediatric MS (pMS). We analysed plasma proteins in pMS by an untargeted proteomic approach. Patients with pMS (Group pMS, n = 33), patients with demyelinating disease not meeting pMS diagnostic criteria (unclassified demyelinating disease, Group U, n = 4) and age-matched healthy subjects (Group C, n = 40) were included. Plasma proteomic analysis was performed using Q-TOF LC/MS. Proteins having fold change >1.2 and found to be statistically different (p 
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2020.577359