Impaired micronutrients and prealbumin in patients with established and very early systemic sclerosis

OBJECTIVESGastrointestinal involvement and impaired nutritional status are frequent in patients with systemic sclerosis (SSc). Hereby, we hypothesised that micronutrients and/or prealbumin could be deficitary in SSc. METHODSPatients with SSc and very early SSc (veSSc) were prospectively included. Cl...

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Published in:Clinical and experimental rheumatology 2020-01, Vol.38 Suppl 125 (3), p.120-126
Main Authors: Läubli, Jasmin, Dobrota, Rucsandra, Maurer, Britta, Jordan, Suzana, Misselwitz, Benjamin, Fox, Mark, Distler, Oliver
Format: Article
Language:English
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Summary:OBJECTIVESGastrointestinal involvement and impaired nutritional status are frequent in patients with systemic sclerosis (SSc). Hereby, we hypothesised that micronutrients and/or prealbumin could be deficitary in SSc. METHODSPatients with SSc and very early SSc (veSSc) were prospectively included. Clinical assessment, data recording and quality controls followed EUSTAR standards. The UCLA SCTCGIT 2.0 questionnaire was applied and the serum levels of zinc, selenium, prealbumin, holotranscobalamin, folic acid were measured. RESULTSHalf (52.4%) of the 176 patients with established SSc showed a deficiency in at least one of the measured nutrients. The most frequent deficit was seen in folic acid (17.9%), followed closely by selenium, prealbumin and zinc (around 15% each). Nearly a fifth (19%) of these patients had multiple deficiencies. Patients with more severe disease, including advanced skin fibrosis, positive ACR 1980 classification criteria, anemia and elevated serum inflammation markers were more likely to be nutrient deficient. Lower BMI
ISSN:0392-856X