Acute liver failure and HELLP syndrome: A clinical case and literature review

HELLP syndrome is a pregnancy-related liver disease associated with increased maternal and foetal mortality. In rare cases, it can lead to the development of a subcapsular hepatic haematoma as well as its rupture. This rupture is life-threatening if not urgently treated. We describe a clinical case...

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Bibliographic Details
Published in:	Clinics and research in hepatology and gastroenterology 2021-03, Vol.45 (2), p.101498-101498, Article 101498
Main Authors:	Mazzola, Alessandra, Magro, Bianca, Perdigao, Fabiano, Charlotte, Fréderic, Atif, Muhammad, Goumard, Claire, Scatton, Olivier, Conti, Filomena
Format:	Article
Language:	eng
Subjects:	Haematoma HELLP syndrome Liver necrosis Liver transplantation
Online Access:	Get full text
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Summary:	HELLP syndrome is a pregnancy-related liver disease associated with increased maternal and foetal mortality. In rare cases, it can lead to the development of a subcapsular hepatic haematoma as well as its rupture. This rupture is life-threatening if not urgently treated. We describe a clinical case of HELLP syndrome involving a ruptured subcapsular liver haematoma and contextualise this with a literature overview. A 39-year-old woman of 40 weeks’ gestation presented to her local Emergency Department with symptoms and serology classically associated with HELLP syndrome. However, she clinically deteriorated and developed a ruptured subcapsular haematoma. She underwent an emergency Caesarean section at her initial hospital. Upon clinical stabilisation, she was transferred to our transplant unit for an urgent liver transplant. LT is a life-saving procedure for patients with acute liver failure secondary to HELLP syndrome. These patients should be immediately referred to a high-volume transplant centre.
ISSN:	2210-7401 2210-741X