Influence of Sex and Age on Muscle Sympathetic Nerve Activity of Healthy Normotensive Adults

Influence of Sex and Age on Muscle Sympathetic Nerve Activity of Healthy Normotensive Adults

As with blood pressure, age-related changes in muscle sympathetic nerve activity (MSNA) may differ nonlinearly between sexes. Data acquired from 398 male (age39±17; range18–78 years [mean±SD]) and 260 female (age37±18; range18–81 years) normotensive healthy nonmedicated volunteers were analyzed usin...

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2020-09, Vol.76 (3), p.997-1005
Main Authors: Keir, Daniel A, Badrov, Mark B, Tomlinson, George, Notarius, Catherine F, Kimmerly, Derek S, Millar, Philip J, Shoemaker, J Kevin, Floras, John S
Format: Article
Language:eng
Subjects:
Adult
Age Factors
Aged
Blood Pressure - physiology
Blood Pressure Determination - methods
Blood Pressure Determination - statistics & numerical data
Body Mass Index
Correlation of Data
Female
Healthy Aging - physiology
Humans
Male
Muscle, Skeletal - innervation
Sex Factors
Sympathetic Nervous System - physiology
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Summary:As with blood pressure, age-related changes in muscle sympathetic nerve activity (MSNA) may differ nonlinearly between sexes. Data acquired from 398 male (age39±17; range18–78 years [mean±SD]) and 260 female (age37±18; range18–81 years) normotensive healthy nonmedicated volunteers were analyzed using linear regression models with resting MSNA burst frequency as the outcome and the predictors sex, age, MSNA, blood pressure, and body mass index modelled with natural cubic splines. Age and body mass index contributed 41% and 11%, respectively, of MSNA variance in females and 23% and 1% in males. Overall, changes in MSNA with age were sigmoidal. At age 20, mean MSNA of males and females were similar, then diverged significantly, reaching in women a nadir at age 30. After 30, MSNA increased nonlinearly in both sexes. Both MSNA discharge and blood pressure were lower in females until age 50 (17±9 versus 25±10 bursts·min; P
ISSN:0194-911X
1524-4563