Primary Intracranial Angiomatoid Fibrous Histiocytoma: Two Case Reports and Literature Review

Angiomatoid fibrous histiocytoma (AFH) is a rare, fibrohistiocytic, soft-tissue neoplasm. Intracranial AFH is extremely rare. Here we present 2 pediatric cases of intracranial AFH and perform a literature review on this disease entity. We present 2 cases. The first case is a 10-year-old boy who pres...

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Bibliographic Details
Published in:World neurosurgery 2020-11, Vol.143, p.398-404
Main Authors: Bin Abdulqader, Sarah, Altuhaini, Khalid, Tallab, Raghad, AlTurkistani, Abdulellah, Alhussinan, Modhi, Alghamdi, Saad, Al Saidi, Khelad, Almalki, Salman, Alshakweer, Wafa, Alotaibi, Fahad E.
Format: Article
Language:English
Subjects:
Angiomatoid fibrous histiocytoma
Brain Neoplasms - genetics
Brain Neoplasms - pathology
Brain Neoplasms - surgery
Child
Children
Female
Gene Rearrangement
Histiocytoma, Malignant Fibrous - genetics
Histiocytoma, Malignant Fibrous - pathology
Histiocytoma, Malignant Fibrous - surgery
Humans
Intracranial
Male
RNA-Binding Protein EWS - genetics
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Summary:Angiomatoid fibrous histiocytoma (AFH) is a rare, fibrohistiocytic, soft-tissue neoplasm. Intracranial AFH is extremely rare. Here we present 2 pediatric cases of intracranial AFH and perform a literature review on this disease entity. We present 2 cases. The first case is a 10-year-old boy who presented with seizures and hemiparesis. The second case is an 11-year-old girl who presented with 2-year history of seizures. Radiologic images demonstrated right frontal lesions in both patients. Complete surgical resection was achieved. Histopathological findings established the diagnosis of intracranial AFH confirmed with fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction testing that demonstrated EWSR1 gene rearrangement in both cases. Twenty-two cases of intracranial AFH have been previously documented, with the majority of lesions located in the frontal lobe. Most cases occurred in adolescents and young adults, with a slight female predilection. Headaches and seizures constituted the most common clinical presentation. Complete surgical resection remains the standard of care in the management of this pathology.
ISSN:1878-8750
1878-8769
DOI:10.1016/j.wneu.2020.07.225