Vitamin D, an inflammatory activity marker for spondyloarthritis?

Summary In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis. Therefore, insufficient levels of vitamin D could be used as a marker of inflammation, so they would help to have a better follow-up of the patient....

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Published in:Archives of osteoporosis 2020-12, Vol.15 (1), p.126-126, Article 126
Main Authors: Castro Corredor, David, Ramírez Huaranga, Marco Aurelio, Mínguez Sánchez, María Dolores, Anino Fernández, Joaquín, Mateos Rodríguez, Javier José, Rebollo Giménez, Ana Isabel, González Peñas, Marina, Seoane Romero, Javier, Luque Zafra, Miguel, de Lara Simón, Isabel María, Cuadra Díaz, José Luis
Format: Article
Language:English
Subjects:
Endocrinology
Medicine
Medicine & Public Health
Original Article
Orthopedics
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Summary:Summary In this study, a relationship between low levels of vitamin D and other markers of inflammation is observed in patients with spondyloarthritis. Therefore, insufficient levels of vitamin D could be used as a marker of inflammation, so they would help to have a better follow-up of the patient. Purpose The aim of this study is to determine the association between 25-hydroxyvitamin D deficiency and level of disease activity in patients suffering from spondyloarthritis. Methodology This study is an observational, descriptive and transversal study. A retrospective review of patients with spondyloarthritis under treatment at the Rheumatology Department of Hospital General Universitario de Ciudad Real between September 2016 and September 2018 is under consideration. The association between 25-hydroxyvitamin D deficiency and levels of disease activity was calculated using odds ratio (OR) with a 95% confidence level. Results Initial study developments are reported. A group of 147 patients was analyzed. The average disease activity was 4.3 (according to BASDAI) and 11.4 (according to DAPSA). Twenty-eight percent of patients showed increased levels of acute-phase reactants, and 82% exhibited 25-hydroxyvitamin D deficiency/insufficiency. Analysis of the association between vitamin D deficiency/insufficiency and BASDAI/DAPSA activity degree revealed an OR of 7.9 (CI95%: 2.92–21.23, p  = 
ISSN:1862-3522
1862-3514
DOI:10.1007/s11657-020-00805-5