Low participation rates and disparities in participation in interventional clinical trials for myelodysplastic syndromes

Background The development of novel therapies for the myelodysplastic syndromes (MDS) is hampered by inadequate trial recruitment. Factors contributing to low trial accrual are incompletely understood. Methods This study analyzed a pooled patient database from institutions of the US MDS Clinical Res...

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Bibliographic Details
Published in:Cancer 2020-11, Vol.126 (21), p.4735-4743
Main Authors: Brierley, Charlotte K., Zabor, Emily C., Komrokji, Rami S., DeZern, Amy E., Roboz, Gail J., Brunner, Andrew M., Stone, Richard M., Sekeres, Mikkael A., Steensma, David P.
Format: Article
Language:English
Subjects:
Clinical trials
Consortia
Disorders
enrollment barriers
Health hazards
Health risks
Health services
Medical treatment
Minority & ethnic groups
Myelodysplastic syndrome
myelodysplastic syndromes
Oncology
Participation
Patients
racial disparities
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Summary:Background The development of novel therapies for the myelodysplastic syndromes (MDS) is hampered by inadequate trial recruitment. Factors contributing to low trial accrual are incompletely understood. Methods This study analyzed a pooled patient database from institutions of the US MDS Clinical Research Consortium to compare the characteristics of participants in interventional trials with those of patients who did not enroll in a trial. Results Data were identified for 1919 patients with MDS, and 449 of these patients (23%) participated in an interventional clinical trial. The median age of all patients was 68 years, and 64% were male. Patients who participated in trials were significantly younger than nonparticipants (P = .014), and men were more likely to participate in a trial (71% of trial participants were male, whereas 61% of nonparticipants were; P 
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.33105