Role of inflammatory and pain genes polymorphisms in temporomandibular disorder and pressure pain sensitivity

•SNP IL6−174 predict higher pain sensitivity in the TMJ and anterior temporalis muscle in TMD group.•SNP COMT Val158Met predict higher pain sensitivity in the masseter muscle in the TMD group.•Higher prevalence of SNP TNFA-308 is related with TMD. The aim of this study was to assess the correlation...

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Published in:Archives of oral biology 2020-10, Vol.118, p.104854-104854, Article 104854
Main Authors: Pinto Fiamengui, Lívia Maria Sales, Furquim, Bruno D'Aurea, De la Torre Canales, Giancarlo, Fonseca Carvalho Soares, Flávia, Poluha, Rodrigo Lorenzi, Palanch Repeke, Carlos Eduardo, Bonjardim, Leonardo Rigoldi, Garlet, Gustavo Pompermaier, Rodrigues Conti, Paulo César
Format: Article
Language:English
Subjects:
Adult
Dentistry
Genetic polymorphism
Genotype
Humans
Inflammation - genetics
Interleukin-6 - genetics
Masseter Muscle
Pain pressure threshold
Pain sensitivity
Pain Threshold
Polymorphism, Single Nucleotide
Pressure
Temporal Muscle
Temporomandibular disorders
Temporomandibular Joint - physiopathology
Temporomandibular Joint Disorders - genetics
Young Adult
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Summary:•SNP IL6−174 predict higher pain sensitivity in the TMJ and anterior temporalis muscle in TMD group.•SNP COMT Val158Met predict higher pain sensitivity in the masseter muscle in the TMD group.•Higher prevalence of SNP TNFA-308 is related with TMD. The aim of this study was to assess the correlation of inflammatory and pain genes polymorphisms with the presence of temporomandibular disorder (TMD) patients and with pressure pain sensitivity. Data was collected from 268 consecutive subjects at Bauru School of Dentistry. Subjects aged younger than 20 years, with dental and neuropathic pain, sinusitis, cognitive and neurologic disorder were excluded. Included subjects were evaluated using the Research Diagnostic Criteria for Temporomandibular disorders and divided into two groups: TMD cases and healthy controls. Groups were submitted to pressure pain threshold (PPT) test for the temporomandibular joint, anterior temporalis and masseter muscles and genotyped for Val158Met, IL6−174, IL-1β-3954 and TNFA-308. Student’s t-test and Pearson chi-square test were used to comparisons between groups. A linear multiple regression was used to evaluate the influence of genetics variables on the PPT and a bivariate analysis was used to assesses the influence of genetics variables on pain sensitivity below the PPT cut off of the structures in TMD group. TMD group showed significantly lower PPT values for all structures when compared with control group (p < 0.001). SNP IL6−174 predicted higher pain sensitivity in the temporomandibular joint (p < 0.005) and in anterior temporalis muscle (p < 0.044) and SNP Val158Met in the masseter muscle (p < 0.038); when TMD group was divided according to PPT cut-off values the SNP Val158Met influenced increase pain sensibility in the masseter muscle. TNFA-308 was associated with TMD and SNP IL6−174 and SNP Val158Met influenced pain sensitivity of patients with TMD.
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2020.104854