Antimicrobial activity of functionalised carbon nanotubes against pathogenic microorganisms

Carbon nanotubes represent one of the best examples of novel nanostructures, exhibit a range of extraordinary physical properties, strong antimicrobial activity and can pierce bacterial cell walls. This investigation handles the antimicrobial activity of functionalised multiwall carbon nanotubes (F-...

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Bibliographic Details
Published in:IET nanobiotechnology 2020-08, Vol.14 (6), p.457-464
Main Authors: Abo-Neima, Sahar E, Motaweh, Hussein A, Elsehly, Emad M
Format: Article
Language:English
Subjects:
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
antibacterial activity
antimicrobial activity
antimicrobial material
Bacteria - drug effects
bacterial cell walls
bacterial growth measurements
bactericidal performance
biomedical devices
biomedical materials
cellular biophysics
cellular death
cellular reliability
damage mechanism
dielectric conductivity
E. coli
electrical conductivity
functionalised multiwall carbon nanotubes
F‐MWNTs
Microbial Sensitivity Tests
Microbial Viability - drug effects
microenvironment
microorganisms
morphological changes
multi‐wall carbon nanotubes
nanomedicine
Nanotubes, Carbon - chemistry
oxidative stress
pathogenic microorganisms
permittivity
physical properties
Research Article
S. aureus
toxic substances
toxicology
transmission electron microscopy
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Summary:Carbon nanotubes represent one of the best examples of novel nanostructures, exhibit a range of extraordinary physical properties, strong antimicrobial activity and can pierce bacterial cell walls. This investigation handles the antimicrobial activity of functionalised multiwall carbon nanotubes (F-MWNTs) as an alternative antimicrobial material compared to the commercial antibiotics. Antibacterial activities of F-MWNTs are investigated through two different kinds of bacteria, E. coli and S. aureus. The results demonstrate that the best concentration of F-MWNTs for the maximum inhibition and antibacterial functionality is 80 and 60 μg/ml for E. coli and S. aureus, respectively. The transmission electron microscope reveals the morphological changes damage mechanism for the cellular reliability on these microorganisms. F-MWNTs are capable of biologically isolating the cell from their microenvironment, contributing to the development of toxic substances and placing the cell under oxidative stress leading to cellular death. The efficiency of F-MWNTs is compared with the common antibiotics and shows an enhancement in the inhibitory effect with percentages reaches 85%. To account for the bactericidal performance of F-MWNTs towards these pathogens, the dielectric conductivity and the bacterial growth measurements are conducted. The present study endeavour that F-MWNTs could be exploited in biomedical devices and altering systems for hospital and industrial cleaning applications.
ISSN:1751-8741
1751-875X
1751-875X
DOI:10.1049/iet-nbt.2019.0342