Factors affecting seizure outcome in Long-term epilepsy associated tumors (LEATs) in children and young adolescents

•The shorter duration of symptoms, partial/focal seizures and gross total excision were predictors of a good seizure-outcome.•Age of the patient and the histopathology of the tumor does not affect seizure-outcome on comparing GNTs with non GNTs.•Early surgery in these cases with gross total excision...

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Published in:Clinical neurology and neurosurgery 2020-10, Vol.197, p.106104-106104, Article 106104
Main Authors: Mehrotra, Anant, Singh, Suyash, Kanjilal, Soumen, Pal, Lili, Paliwal, Vimal K., Sardhara, Jayesh, Verma, Pawan K., Maurya, Ved P., Bhaisora, Kamlesh S., Das, Kuntal K., Srivastava, Arun K., Jaiswal, Awadhesh K., Behari, Sanjay
Format: Article
Language:English
Subjects:
Age
Brain cancer
Brain tumors
Convulsions & seizures
Engel
Epilepsy
Glioneuronal tumors
Long-term epilepsy associated tumors (LEATs)
Neurology
Patients
Pediatric
Pediatrics
Seizure
Seizures
Teenagers
Tumors
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Summary:•The shorter duration of symptoms, partial/focal seizures and gross total excision were predictors of a good seizure-outcome.•Age of the patient and the histopathology of the tumor does not affect seizure-outcome on comparing GNTs with non GNTs.•Early surgery in these cases with gross total excision may improve the likelihood of a good seizure control. Tumors with seizures as primary mode of presentation are collectively called Long-term epilepsy associated tumors (LEATs or Epileptomas). The overall survival is good so ‘seizure outcome’ becomes the primary goal rather than neuro-oncological outcome. A retrospective analysis of our surgical database (2015−19) was done to find operated patients of intra-axial brain tumors with age less than 25-years and who had presented with seizures. The mean age at presentation was 16.44 years (SD + 6.82 years). Complex partial seizures/focal unaware seizures were the most common type of seizures encountered (n = 22) with mean duration of seizures was 49.50 months (SD + 31.04 months). The most common pathology was glioneuronal tumors (GNTs) (n = 17). Gross total resection (GTR) group had a significantly better seizure outcome as compared with the Subtotal resection (STR) group (p = 0.006). Presence of focal or partial seizure was a significant factor pointing towards a better seizure control (p = 0.005). The shorter duration of symptoms, partial/focal seizures and gross total excision were predictors of a good seizure-outcome. Age of the patient and the histopathology of the tumor does not affect seizure-outcome on comparing GNTs with non GNTs.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2020.106104