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Investigation of isomeric tetra-cationic porphyrin activity with peripheral [Pd(bpy)Cl]+ units by antimicrobial photodynamic therapy
[Display omitted] •Application of tetra-cationic Pd(II)-porphyrins against bacteria.•Use of porphyrins in the treatment of bacteriosis.•3-PdTPyP tetra-cationic porphyrin meta isomer is very effectiveness in photo-inactivation of bacteria. In this work, we report the antimicrobial photoinactivation u...
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Published in: | Photodiagnosis and photodynamic therapy 2020-09, Vol.31, p.101920-101920, Article 101920 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | [Display omitted]
•Application of tetra-cationic Pd(II)-porphyrins against bacteria.•Use of porphyrins in the treatment of bacteriosis.•3-PdTPyP tetra-cationic porphyrin meta isomer is very effectiveness in photo-inactivation of bacteria.
In this work, we report the antimicrobial photoinactivation using tetra-cationic porphyrins with peripheral palladium(II) complexes against bacterial strains. Two different isomeric Pd(II)-porphyrins were used and applied in PDI experiments in the strains Gram negative bacilli Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa and a Gram positive cocci Staphylococcus aureus. All experiments are conducted with adequate concentration (without aggregation) of photosensitizer under white-light irradiation over 2 h . We showed that the most effective PS caused a significative reduction in the concentration of viable bacteria. The present results show that porphyrin with positively charge at meta position (3-PtTPyP) are more efficient photosensitizer against bacteria strains. In this way, tetra-cationic porphyrins might be promising antibacterial PDI agents with potential applications in clinical cases. |
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ISSN: | 1572-1000 1873-1597 |
DOI: | 10.1016/j.pdpdt.2020.101920 |