Identifying putative cerebrospinal fluid biomarkers of amyotrophic lateral sclerosis in a north Indian population

Introduction Evidence‐based information about cerebrospinal fluid (CSF) levels of biomarkers in patients with amyotrophic lateral sclerosis (ALS) is limited. Methods Vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor 2 (VEGFR2), optineurin (OPTN),...

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Published in:Muscle & nerve 2020-10, Vol.62 (4), p.528-533
Main Authors: Khosla, Radhika, Rain, Manjari, Chawathey, Shreyas, Modgil, Shweta, Tyagi, Rahul, Thakur, Keshav, Pannu, Viraaj, Sharma, Suresh Kumar, Anand, Akshay
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
amyotrophic lateral sclerosis, angiogenesis, cerebrospinal fluid, muscle wasting, neuromuscular disorder
Angiogenin
Biomarkers
Cerebrospinal fluid
Clinical trials
Deoxyribonucleic acid
DNA
Growth factors
Immunoassay
Monocyte chemoattractant protein
Monocytes
Proteins
Receptors
Vascular endothelial growth factor
Vascular endothelial growth factor receptor 2
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Summary:Introduction Evidence‐based information about cerebrospinal fluid (CSF) levels of biomarkers in patients with amyotrophic lateral sclerosis (ALS) is limited. Methods Vascular endothelial growth factor (VEGF) and its receptor vascular endothelial growth factor receptor 2 (VEGFR2), optineurin (OPTN), monocyte chemoattractant protein‐1 (MCP‐1), angiogenin (ANG), and TAR DNA‐binding protein (TDP‐43) were quantified by enzyme‐linked immunoassay in the CSF of 54 patients with sporadic ALS and 32 controls in a case‐control study design. Results CSF levels of VEGF (P = .014) and ANG (P = .009) were decreased, whereas VEGFR2 was higher (P = .002) in patients with ALS than in controls. TDP‐43 positively correlated with MCP‐1 (P = .003), VEGF (P 
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.27026