Contactless electrospray ionization mass spectrometry for direct detection of analytes in living organisms

In this study, we developed contactless electrospray ionization mass spectrometry (ESI‐MS) for in vivo analysis of living organisms in different applications. The in vivo sampling and direct analysis processess of living organisms were integrated into an operation that only requires the organism clo...

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Bibliographic Details
Published in:Journal of mass spectrometry. 2021-04, Vol.56 (4), p.e4539-n/a
Main Authors: Li, Wen, Yao, Ya‐Nan, Wu, Lin, Wang, Lei, Hu, Bin
Format: Article
Language:English
Subjects:
Analysis
Animals
Cell Line, Tumor
Chemical residues
contactless electrospray ionization
Crustacea
Detection
Electrospraying
Fishes
High voltage
in vivo analysis
In vivo methods and tests
in vivo sampling
Ionization
Ions
living organism
Mass spectrometry
Mass spectroscopy
Metabolites
Metabolome
Mice
Mice, Inbred BALB C
Mucus - chemistry
Neoplasms, Experimental
Organisms
Pesticides - analysis
Plants - chemistry
Scientific imaging
Spectrometry, Mass, Electrospray Ionization - methods
Spectroscopy
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Summary:In this study, we developed contactless electrospray ionization mass spectrometry (ESI‐MS) for in vivo analysis of living organisms in different applications. The in vivo sampling and direct analysis processess of living organisms were integrated into an operation that only requires the organism close to MS inlet that was applied to a high voltage. Living plants and animals were directly induced to generate spray ionization. Direct detection and in vivo monitoring of metabolites and chemical residues in various living organisms were successfully demonstrated. Analysis of a single sample could be completed within 30 s. Overall, contactless ESI‐MS provides an attractive in vivo method to straightforward investigation of living organisms.
ISSN:1076-5174
1096-9888
DOI:10.1002/jms.4539